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The Effects of the Combined Co-Expression of GroEL/ES and Trigger Factor Chaperones on Orthopoxvirus Phospholipase F13 Production in .
BioTech (Basel)
December 2024
State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
Heterologous protein expression often faces significant challenges, particularly when the target protein has posttranslational modifications, is toxic, or is prone to misfolding. These issues can result in low expression levels, aggregation, or even cell death. Such problems are exemplified by the expression of phospholipase p37, a critical target for chemotherapeutic drugs against pathogenic human orthopoxviruses, including monkeypox and smallpox viruses.
View Article and Find Full Text PDFBurden and predictors of M-pox suspected cases in a rural setting of Cameroon: implications for developing countries.
J Infect Dev Ctries
November 2024
Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.
Article Synopsis
- M-pox is a rapidly spreading pathogen in developing countries, particularly in Cameroon, raising concerns about its health impact and the lack of data on its determinants.
- A community-based study conducted in the Ayos Health District found a suspected M-pox case rate of 25%, with various factors like history of infections and contact with infected individuals or animals significantly linked to its prevalence.
- The study highlights the need for enhanced surveillance and public health interventions in rural communities to better address the resurgence of M-pox.
Effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine against mpox infection: emulation of a target trial.
BMJ
September 2024
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Article Synopsis
- This study aimed to evaluate how effective the MVA-BN vaccine is at preventing mpox infections in real-world settings, specifically in Ontario, Canada.
- Researchers matched vaccinated men (who received the vaccine at least 15 days prior) with unvaccinated men based on several health and demographic factors, assessing the rate of mpox infections over a 153-day period.
- Results indicated that the MVA-BN vaccine was about 58% effective in reducing the risk of mpox infection compared to unvaccinated individuals, suggesting that it can be a valuable tool in controlling outbreaks.
Investigating seroprevalence of IgG antibodies against Monkeypox Virus (MPXV) in a cohort of people living with HIV (PLWH) in Rome, during the 2022 outbreak: Moving beyond traditional at-risk populations.
Travel Med Infect Dis
November 2024
UOC Malattie Infettive, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. Electronic address:
Background: High incidence mpox rates suggest asymptomatic individuals may contribute to virus transmission. We undertook this study to assess the seroprevalence of IgG anti-MPXV in a cohort of asymptomatic PLWH, to analyze the size of the phenomenon of asymptomatic infections.
Materials And Methods: From October 2022 to March 2023 we serially collected serum samples from PLWH attending our Clinic.
Vaccine effectiveness of 3rd generation mpox vaccines against mpox and disease severity: A systematic review and meta-analysis.
Vaccine
November 2024
Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern, Dallas, TX, USA.
Introduction: Before the global mpox outbreak which began in 2022, the real-world vaccine effectiveness (VE) of mpox vaccines was unknown. We quantified the VE in the global population of 3rd generation or later mpox vaccines (MVA-BN, LC16m8, OrthopoxVac) compared with unvaccinated or other vaccinated states for infection, hospitalization and death. VE was stratified by 1-dose and 2-doses and post-exposure prophylaxis (PEP).
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