Haemostasis starts through adhesion of platelets to the subendothelium. Subsequently, ADP and prostaglandins are secreted by the adhered platelets, inducing aggregation of further platelets. The so formed platelet plug stops the bleeding. Congenital disorders of vessel wall and platelets are rare, but acquired abnormalities occur frequently. Usually the consequences of these abnormalities can be handled by local haemostatic action and by the use of antifibrinolytic agents.
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