Haematological malignancies like acute and chronic leukemias, malignant lymphoma and plasma cell disorders may exhibit oral manifestation during their course. In this article the oral manifestation of a number of haematological malignancies presented in the oral cavity as well as the complications of the treatment are described.
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J Clin Microbiol
January 2025
Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
Invasive pulmonary infections are a significant cause of morbidity and mortality in patients with hematological malignancies and hematopoietic stem cell transplantation (HCT) recipients. A delay in identifying a causative agent may result in late initiation of appropriate treatment and adverse clinical outcomes. We examine the diagnostic utility of PCR-based assays in evaluating invasive pulmonary infections from bronchoalveolar lavage (BAL).
View Article and Find Full Text PDFAdv Appl Bioinform Chem
January 2025
Department of Information Technology, Mutah University, Al-Karak, Jordan.
Purpose: The incidence of cancer, which is a serious public health concern, is increasing. A predictive analysis driven by machine learning was integrated with haematology parameters to create a method for the simultaneous diagnosis of several malignancies at different stages.
Patients And Methods: We analysed a newly collected dataset from various hospitals in Jordan comprising 19,537 laboratory reports (6,280 cancer and 13,257 noncancer cases).
World J Gastrointest Oncol
January 2025
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples 80131, Campania, Italy.
Background: Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase (DPD), encoded by the gene. About 7% of the European population is a carrier of gene polymorphisms associated with reduced DPD enzyme activity.
Aim: To assess the prevalence of polymorphisms and their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal malignancies.
Ecancermedicalscience
October 2024
Muhimbili University of Health and Allied Sciences (MUHAS), Dar es salaam 11103, Tanzania.
Acute leukemia (AL) is a diverse group of hematological malignancies characterised by the accumulation of immature blast cells in the bone marrow. Accurate classification into acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) is essential for treatment and prognosis. This study aimed to assess the performance of glass slide morphology (GSM) using a light microscope versus whole slide imaging (WSI) in diagnosing and classifying AL, using flow cytometry as the gold standard test.
View Article and Find Full Text PDFCureus
December 2024
Department of Psychiatry, Texas Tech University Health Sciences Center, Odessa, USA.
Schizophrenia is a chronic psychiatric disorder with a complex etiology involving genetic, neurobiological, and environmental factors. Many individuals with schizophrenia experience treatment resistance despite advances in pharmacologic and non-pharmacologic interventions. Immune dysregulation, characterized by altered cytokine levels, immune-related gene expression, and neuroinflammation, plays a critical role in schizophrenia's pathogenesis.
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