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Nitro-fatty acids modulate germination onset through S-nitrosothiol metabolism.
Plant Physiol
January 2025
Group of Biochemistry and Cell Signalling in Nitric Oxide, University Institute for Research in Olive Groves and Olive Oils, Department of Experimental Biology, Faculty of Experimental Sciences, Campus "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain.
-Nitro-fatty acids (NO2-FAs) have emerged as key components of nitric oxide (NO) signalling in eukaryotes. We previously described how nitro-linolenic acid (NO2-Ln), the major NO2-FA detected in plants, regulates S-nitrosoglutathione (GSNO) levels in Arabidopsis (Arabidopsis thaliana). However, the underlying molecular mechanisms remain undefined.
View Article and Find Full Text PDFMulti-dimensional bio mass cytometry: simultaneous analysis of cytoplasmic proteins and metabolites on single cells.
Chem Sci
January 2025
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University Beijing 100871 China
Single-cell multi-dimensional analysis enables more profound biological insight, providing a comprehensive understanding of cell physiological processes. Due to limited cellular contents, the lack of protein and metabolite amplification ability, and the complex cytoplasmic environment, the simultaneous analysis of intracellular proteins and metabolites remains challenging. Herein, we proposed a multi-dimensional bio mass cytometry platform characterized by protein signal conversion and amplification through an orthogonal exogenous enzymatic reaction.
View Article and Find Full Text PDFS-Sulfenylation-mediated inhibition of the GSNOR1 activity regulates ovule development in Arabidopsis.
J Genet Genomics
January 2025
State Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Reactive oxygen species (ROS) and nitric oxide (NO) are two critical classes of signaling molecules that regulate plant development and stress responses. The intracellular level of S-nitrosoglutathione (GSNO), a major bioactive NO species, is regulated by the highly conserved GSNO reductase (GSNOR). However, the molecular mechanisms underlying ROS-mediated regulation of GSNOR remain largely unclear.
View Article and Find Full Text PDFImproving Soybean Germination and Nodule Development with Nitric Oxide-Releasing Polymeric Nanoparticles.
Plants (Basel)
December 2024
Department of Animal and Plant Biology, Londrina State University, Londrina 86057-970, PR, Brazil.
Nitric oxide (NO) is a multifunctional signaling molecule in plants, playing key roles in germination, microbial symbiosis, and nodule formation. However, its instability requires innovative approaches, such as using nanoencapsulated NO donors, to prolong its effects. This study evaluated the impact of treating soybean () seeds with the NO donor S-nitrosoglutathione (GSNO), encapsulated in polymeric nanoparticles, on the germination, nodulation, and plant growth.
View Article and Find Full Text PDFTumor Microenvironment-Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression.
Adv Sci (Weinh)
December 2024
Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.
The clinical efficacy of immune checkpoint blockade (ICB) therapy is significantly compromised in the metabolically disordered tumor microenvironment (TME), posing a formidable challenge that cannot be ignored in current antitumor strategies. In this study, TME-responsive nanoparticles (HMP1G NPs) loaded with 1-methyltryptophan (1-MT; an indoleamine 2,3-dioxygenase 1 [IDO1] inhibitor,) and S-nitrosoglutathione (GSNO; a nitric oxide donor) is developed to enhance the therapeutic efficacy of 1-MT-mediated ICB. The HMP1G NPs responded to H and glutathione in the TME, releasing Mn, GSNO, and 1-MT.
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