The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those subfamilies have been characterized by overlapping pharmacological properties, amino acid sequences, gene organization, and second messenger coupling pathways. Post-genomic modifications, such as alternative mRNA splicing or mRNA editing, creates at least 20 more G-protein-coupled 5-HT receptors, such that there are at least 30 distinct 5-HT receptors that signal through G-proteins. This review will focus on what is known about the signaling linkages of the G-protein-linked 5-HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0163-7258(01)00169-3DOI Listing

Publication Analysis

Top Keywords

5-ht receptors
16
5-ht
5
receptors
5
multiplicity mechanisms
4
mechanisms serotonin
4
serotonin receptor
4
receptor signal
4
signal transduction
4
transduction serotonin
4
serotonin 5-hydroxytryptamine
4

Similar Publications

Population pharmacokinetics of blonanserin in Japanese adolescent and adult patients with schizophrenia.

Drug Metab Pharmacokinet

November 2024

Clinical Research, Drug Development Division, Sumitomo Pharma Co., Ltd., 33-94, Enoki-cho, Suita, Osaka, 564-0053, Japan. Electronic address:

The second-generation antipsychotic blonanserin is a highly selective, full antagonist of dopamine D and D and serotonin 5-HT receptors. It is currently prescribed for patients with schizophrenia in Japan. We aimed to develop a population pharmacokinetic model of oral blonanserin, including data from 12 to 77 years old patients, to assess the covariates that influence blonanserin pharmacokinetics and evaluate appropriate dosage regimens in adolescents versus adults.

View Article and Find Full Text PDF

Biomarkers.

Alzheimers Dement

December 2024

Brunel University London, London, UK.

Background: Psychotic symptoms may manifest in Alzheimer's disease (AD), especially in advanced disease stages and in patients with higher polygenic risk scores for schizophrenia (SCZ-PRS). Such genetic risk seems also to influence grey matter volume (GMV) alterations in patients with psychosis. Since multiple neurotransmitter systems, namely dopamine (DA) and serotonin (5-HT), have been implicated in psychosis, the aim of this study was to investigate whether a SCZ-PRS may explain variance in the association between GMV and the cerebral distribution of DA and 5-HT.

View Article and Find Full Text PDF

Background: Tau protein tangles have been recently shown to accumulate in multiple brainstem nuclei in pre-cortical Alzheimer's disease (AD) stages. The impact of neurotransmission alterations on brain atrophy and their genetic correlates in AD remain unexplored. Therefore, the aims of this study were: 1) to investigate associations between grey matter (GM) loss across the AD continuum and the distribution of multiple neurotransmitter receptors/transporters; 2) to investigate the impact of polygenic risk scores for AD (PRSs) on such associations.

View Article and Find Full Text PDF

Background: A decline in memory is a hallmark of Alzheimer's disease (AD). Experiments in rodents and post-mortem studies in humans with AD suggest that serotonin (5-HT) plays a role in memory, but the molecular and neural mechanisms mediating its effects are unknown.

Method: 100,000 individuals in UK Biobank were studied for the role of serotonin 2C receptor (5-HTR) in the regulation of memory.

View Article and Find Full Text PDF

Developing Topics.

Alzheimers Dement

December 2024

Faculty of Medicine, Arish University, Arish, North Sinai, Egypt.

Background: Lingual taste cells (LTCs) are taste buds' sensory cells that modulate gustation. This study's aim is to assess whether it can be successfully implanted in hippocampus, modulating learning and memory deficits observed in Alzheimer's Dementia (AD).

Methods: Retrospective trials on rodents i.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!