Electrolysis is a method of tissue ablation that creates chemical species and a pH gradient in response to direct current. Initial studies of electrolysis in animal models and humans have shown that it is a safe, predictable and effective process for destroying normal and tumour-bearing liver in a linear, dose-dependent manner. Presently, the amount of current that is applied (in coulombs) has to be calculated using historical data, with inherent inaccuracy. The present study tested whether pH could be used as a real-time monitor in order to predict more accurately the extent of necrosis. A total of 70 electrolytic lesions were created in 14 pigs, with pH monitoring of the lesion edge. The normal range of pH values was 6.5-8.7. A pH of less than 6 (at the anode) or more than 9 (at the cathode) reflected total cellular necrosis. When a pH value was recorded between 6.0 and 6.5 at the anode or between 8.7 and 9.0 at the cathode, the presence of necrosis was variable. In conclusion, during electrolytic ablation, pH measurement can monitor the extent of the induced necrosis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Floodplain forests drive fruit-eating fish diversity at the Amazon Basin-scale.
Proc Natl Acad Sci U S A
January 2025
Centre de Recherche sur la Biodiversité et l'Environnement, Université de Toulouse, Institut de Recherche pour le Développement, Institut National Polytechnique de Toulouse, Université Toulouse 3 - Paul Sabatier, Toulouse F-31062, France.
Unlike most rivers globally, nearly all lowland Amazonian rivers have unregulated flow, supporting seasonally flooded floodplain forests. Floodplain forests harbor a unique tree species assemblage adapted to flooding and specialized fauna, including fruit-eating fish that migrate seasonally into floodplains, favoring expansive floodplain areas. Frugivorous fish are forest-dependent fauna critical to forest regeneration via seed dispersal and support commercial and artisanal fisheries.
View Article and Find Full Text PDFHiking Trails Facilitate the Spread of a Native High-Arctic Species.
Ecol Evol
January 2025
Dynamic Macroecology/Land Change Science Swiss Federal Institute for Forest, Snow and Landscape Research WSL Birmensdorf Switzerland.
High-Arctic environments are facing an elevated pace of warming and increasing human activities, making them more susceptible to the introduction and spread of alien species. We investigated the role of human disturbance in facilitating the spread of a native plant () in a high-Arctic natural environment close to Isfjord Radio station and along adjacent hiking trails at Kapp Linné, Svalbard. We reconstructed the spatial pattern of the arrival and spread of at Kapp Linné by combining historical records of the species occurrence (1928-2018) with a contemporary survey of the plant abundance along the main hiking trail (2023 survey) and tested the relative effects of altitude and proximity to hiking trails on the species density via a generalised linear model (GLM).
View Article and Find Full Text PDFSensitivity and Specificity of a Signaling Question for Surveillance of Cognitive Functioning in Pediatric Sickle Cell Disease.
Pediatr Blood Cancer
January 2025
Division of Hematology, Children's National Hospital, Washington, District of Columbia, USA.
Background: Sickle cell disease (SCD) confers neurological risks that contribute to cognitive and academic difficulties. Clinical guidelines state that cognition should be monitored using signaling questions. However, evidence is lacking regarding the extent to which signaling questions accurately identify children with cognitive issues.
View Article and Find Full Text PDFOptimal Planning Target Volume Margins to Account for Intra-Fractional Prostate Motion Relative to Treatment Duration: A Study Using Real-Time Transperineal Ultrasound Guidance.
J Med Imaging Radiat Oncol
January 2025
Department of Radiation Oncology, Townsville University Hospital, Townsville, Queensland, Australia.
Introduction: Prostate motion during external beam radiotherapy (EBRT) is common and typically managed using fiducial markers and cone beam CT (CBCT) scans for inter-fractional motion correction. However, real-time intra-fractional motion management is less commonly implemented. This study evaluated the extent of intra-fractional prostate motion using transperineal ultrasound (TPUS) and examined the impact of treatment time on prostate motion.
View Article and Find Full Text PDFNighttime light extent and intensity explain the dynamics of human activity in coastal zones.
Sci Rep
January 2025
Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Via Amendola 165/A, 70126, Bari, Italy.
Studying human activity in coastal areas is crucial for urban planning, sustainability, and economic development. However, there is limited evidence of ongoing monitoring of human activities in these areas. Thus, a quantitative analysis of the spatio-temporal changes, trends, and variability of Nighttime light (NTL) in the Italian Coastal Zone over the past decade (2014-2023) was conducted to assess human activity dynamics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!