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Ensifentrine in COPD patients taking long-acting bronchodilators: A pooled post-hoc analysis of the ENHANCE-1/2 studies.
Chron Respir Dis
January 2025
South Texas Veterans Health Care System, University of Texas Health, San Antonio, TX, USA.
Background: The efficacy and safety of ensifentrine, a novel PDE3/PDE4 inhibitor, were previously evaluated in the ENHANCE-1 (NCT04535986) and ENHANCE-2 (NCT04542057) trials. Here, we present a pooled post-hoc subgroup analysis of patients according to background chronic obstructive pulmonary disease (COPD) maintenance medication regimens.
Objective: This analysis aimed to explore the efficacy and safety of ensifentrine in patients receiving long-acting muscarinic antagonists (LAMA) or long-acting beta-agonists with inhaled corticosteroids (LABA + ICS).
Prevalence, risk factors and health-seeking behavior of menstrual disorders among women in India: a review of two-decade evidence.
Glob Health Action
December 2024
Department of Public Health and Mortality Studies, Centre of Demography of Gender, International Institute for Population Sciences, Mumbai, India.
Background: Menstrual health is critical for women of reproductive age. It is also evident that menstrual disorders have contributed to the increasing burden of non-communicable diseases.
Objective: To our knowledge, no literature review explicitly addresses the prevalence, risk factors, and health-seeking behaviour of menstrual disorders in India.
Characterization of the Phosphotransferase from 1101 That Is Responsible for the Biotransformation of Zearalenone.
Toxins (Basel)
January 2025
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
microorganisms play an important role in the zearalenone (ZEA) biotransformation process in natural environments. The phosphotransferase pathway in is both widespread and relatively well conserved. However, the reaction kinetics of these phosphotransferases remain poorly understood, and their catalytic activities are suboptimal.
View Article and Find Full Text PDFEffects of Chlorogenic Acid on In Vitro Maturation and Vitrification Cryopreservation of Sheep Oocytes.
Vet Sci
January 2025
College of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Chlorogenic acid (CGA) has strong antioxidant properties. In order to improve the low maturation rate and poor vitrification freezing effect of sheep oocytes caused by oxidative stress. In this study, oocytes from 200 2-3-year-old Kazakh sheep were collected, and different concentrations of CGA were added to the maturation medium and vitrification freezing solution to study the effects of CGA on the maturation rate, cleavage rate, blastocyst rate, reactive oxygen species (ROS) and glutathione (GSH) levels, mitochondrial membrane potential, and the expression levels of oxidation and apoptosis-related genes in sheep oocytes.
View Article and Find Full Text PDFPlant Detection in RGB Images from Unmanned Aerial Vehicles Using Segmentation by Deep Learning and an Impact of Model Accuracy on Downstream Analysis.
J Imaging
January 2025
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Crop field monitoring using unmanned aerial vehicles (UAVs) is one of the most important technologies for plant growth control in modern precision agriculture. One of the important and widely used tasks in field monitoring is plant stand counting. The accurate identification of plants in field images provides estimates of plant number per unit area, detects missing seedlings, and predicts crop yield.
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