Five novel chromones (1,4-benzopyran-4-ones), among which three are tetracyclic and one contains a sulfonyl group, have been isolated from an Ascomycete, Chaetomium quadrangulatum, as monoamine oxidase inhibitory features, and named chaetoquadrins A (1)-E (5).

Download full-text PDF

Source
http://dx.doi.org/10.1248/cpb.50.330DOI Listing

Publication Analysis

Top Keywords

monoamine oxidase
8
oxidase inhibitory
8
ascomycete chaetomium
8
chaetomium quadrangulatum
8
chromones possessing
4
possessing monoamine
4
inhibitory activity
4
activity ascomycete
4
quadrangulatum novel
4
novel chromones
4

Similar Publications

Exploring DMT: Endogenous Role and Therapeutic Potential.

Neuropharmacology

January 2025

Behavioral Neuroscience Lab, Institute of Psychology, SWPS University.

N,N-Dimethyltryptamine (DMT) is a naturally occurring amine and psychedelic compound, found in plants, animals, and humans. While initial studies reported only trace amounts of DMT in mammalian brains, recent findings have identified alternative methylation pathways and DMT levels comparable to classical neurotransmitters in rodent brains, calling for a re-evaluation of its biological role and exploration of this inconsistency. This study evaluated DMT's biosynthetic pathways, focusing on indolethylamine N-methyltransferase (INMT) and its isoforms, and possible regulatory mechanisms, including alternative routes of synthesis and how physiological conditions, such as stress and hypoxia influence DMT levels.

View Article and Find Full Text PDF

Inhibition of mPFC norepinephrine improved chronic post-thoracotomy pain in adult rats.

Ann Med

December 2025

Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Background: Chronic post-thoracotomy pain (CPTP) is characterized by high incidence, long duration, and severity of pain. Medial prefrontal cortex (mPFC) is a brain region closely associated with chronic pain, and norepinephrine is involved in pain regulation. But the role of mPFC norepinephrine in CPTP and its possible mechanism is unclear.

View Article and Find Full Text PDF

Alzheimer's disease is a neurodegenerative disorder that impairs neurocognitive functions. Acetylcholinesterase, Butyrylcholinesterase, Monoamine Oxidase B, Beta-Secretase, and Glycogen Synthase Kinase Beta play central roles in its pathogenesis. Current medications primarily inhibit AChE but fail to halt or reverse disease progression due to the multifactorial nature of Alzheimer's.

View Article and Find Full Text PDF

Due to the continuous exposure to bisphenol-A (BPA), the current study was conducted to evaluate taurine's neuroprotective action against BPA's adverse effect on the brain. Rats were grouped into control, BPA-treated rats, and taurine + BPA-treated rats. At the end of the 35-day treatment period, the memory of the rats was evaluated using the novel object test and the Y-maze test.

View Article and Find Full Text PDF

Bone metastasis and skeletal-related complications are primary causes of mortality in advanced-stage prostate cancer (PCa). Epigenetic regulation, particularly histone modification, plays a key role in this process; however, the underlying mechanisms remain elusive. In mouse models, JARID1D was an important mediator of both visceral and bone metastases.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!