Structural approach of the mechanism of inhibition of alpha-chymotrypsin by coumarins.

Bioorg Med Chem Lett

Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 rue de Bruxelles, B-5000 Namur, Belgium.

Published: April 2002

A pharmacophore associated to the inhibiton of alpha-chymotrypsin has been built based on the structural and electronic characterization of a series of coumarin derivatives.

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http://dx.doi.org/10.1016/s0960-894x(02)00073-2DOI Listing

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