SAR studies aimed at improving the rate of clearance by the incorporation of a 3,4-diamino-3-cyclobutene-1,2-dione group as an amino acid isostere in a series of VLA-4 integrin antagonists are described.
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| http://dx.doi.org/10.1016/s0960-894x(02)00075-6 | DOI Listing |
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