Presumed pharmacophoric groups of melanocortin peptides (naphthalene, amino or guanidine, and indole moieties) were combined in mimetics molecules looking for their favorable location for activity at melanocortin (MC) receptors. Twenty-two compounds were prepared and tested. The best of these displayed micromolar affinities for the MC receptors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(02)00088-4 | DOI Listing |
Publication Analysis
Top Keywords
indole moieties
8
melanocortin receptors
8
reductive amination
4
amination products
4
products naphthalene
4
naphthalene indole
4
moieties bind
4
bind melanocortin
4
receptors presumed
4
presumed pharmacophoric
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!