3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can be isolated using chiral HPLC or prepared by employing chiral resolution. Cloned maxi-K channels are opened by 1, which demonstrates a brain/plasma ratio >9 in rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(02)00101-4 | DOI Listing |
Publication Analysis
Top Keywords
bms-204352 maxipost
8
synthesis characterization
4
characterization bms-204352
4
maxipost 3-fluorooxindoles
4
3-fluorooxindoles openers
4
openers maxi-k
4
maxi-k potassium
4
potassium channels
4
channels 3-aryl-3-fluorooxindoles
4
3-aryl-3-fluorooxindoles efficiently
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!