AI Article Synopsis
- The study examined bone marrow and blood from a myelodysplastic syndrome patient with trisomy 13 and monoclonal B lymphocytes, using advanced techniques like FISH and HUMARA.
- Trisomy 13 was found in 55% of CD34+ cells but only 5.5% of CD19+ cells, indicating a significant difference in their genetic abnormalities.
- Both CD34+ and CD19+ cells were determined to be monoclonal, but with different patterns of X-chromosome inactivation, suggesting they arose from distinct progenitor stem cells.
Article Abstract
Bone marrow and peripheral blood from a myelodysplastic syndrome patient with trisomy 13 and monoclonal B lymphocytes (without evidence of systemic lymphoma) were investigated for clonal lymphoid lineage involvement using interphase fluorescence in situ hybridization (FISH) and X-chromosome inactivation assay (HUMARA) on CD19+ and CD34+ sorted cells. Trisomy 13 was detected in 55% of CD34+ cells and in 5.5% of CD19+ cells, the latter being comparable to the negative control specimen. X-chromosome inactivation showed both CD34+ and CD19+ cells to be monoclonal, though their inactivated X-chromosome was different. The results strongly suggested that both populations of CD34+ and CD19+ cells have originated from a different progenitor stem cell.
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| http://dx.doi.org/10.1080/10428190210205 | DOI Listing |
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