Effect of dexamethasone on implantation and pregnancy in albino rats.

Indian J Exp Biol

Postgraduate Department of Studies in Zoology, Karnatak University, Dharwad, India.

Published: November 2001

Administration of 3 mg/kg body weight of dexamethasone from day 1 or 3 to 7 of pregnancy did not prevent implantation in albino rats. But the same dose when administered from day 8 to 11 resulted in complete abortion / resorption in all rats. Administration of 2 mg / kg body weight of dexamethasone from day 8 to 11 of pregnancy held no effect on the foetal survival. The results indicate that a high dose of dexamethasone does not affect implantation but the same dose affects the more advanced stages of pregnancy.

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