AI Article Synopsis
- * A study examined the expression levels of the alpha7 nAChR in human fetal brain and spinal cord tissues between 5-11 weeks gestational age, revealing higher levels in certain brain areas (pons, medulla, mesencephalon, and spinal cord) compared to others (cerebellum, cortex, and subcortical forebrain).
- * There was a positive correlation between the expression of alpha7 mRNA and gestational age across most brain regions, indicating that the levels of alpha7
Article Abstract
The alpha7 nicotinic acetylcholine receptor subtype is believed to be involved in the regulation of neuronal growth, differentiation and synapse formation during the development of the human brain. In this study the expression of the alpha7 nicotinic acetylcholine receptor was investigated in human fetal brain and spinal cord of 5-11 weeks gestational age. Both the specific binding of [125I]alpha-bungarotoxin to prenatal brain membranes and the expression of alpha7 mRNA were significantly higher in the pons, medulla oblongata, mesencephalon and spinal cord of 9-11 weeks gestational age compared with cerebellum, cortex and subcortical forebrain. A significant positive correlation between gestational age and the expression of alpha7 mRNA was observed in all brain regions except cortex. A positive correlation was also observed between the gestational age and the [125I]alpha-bungarotoxin binding in the pons, medulla oblongata, mesencephalon, and cerebellum. Consequently, a significant relationship between the alpha7 mRNA levels and the binding sites for [125I]alpha-bungarotoxin was found in the fetal brain. The increasing levels of the alpha7 nicotinic acetylcholine receptor during the first trimester support the important role of nAChRs for the development of the central nervous system.
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| http://dx.doi.org/10.1046/j.0022-3042.2001.00714.x | DOI Listing |
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