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Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome.
Nat Commun
January 2025
School of Natural Sciences, and ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, Australia.
The Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome. In this paper we describe assembly and debugging of the 902,994-bp synthetic Saccharomyces cerevisiae chromosome synXVI of the Sc2.
View Article and Find Full Text PDFTissue specific roles of fatty acid oxidation.
Adv Biol Regul
December 2024
Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Mitochondrial long chain fatty acid β-oxidation is a critical central carbon catabolic process. The importance of fatty acid oxidation is made evident by the life-threatening disease associated with diverse inborn errors in the pathway. While inborn errors show multisystemic requirements for fatty acid oxidation, it is not clear from the clinical presentation of these enzyme deficiencies what the tissue specific roles of the pathway are compared to secondary systemic effects.
View Article and Find Full Text PDFDifferential Diagnosis of Tuberculosis and Sarcoidosis by Immunological Features Using Machine Learning.
Diagnostics (Basel)
September 2024
Department of Mathematics and Computer Science, St. Petersburg State University, 199034 St. Petersburg, Russia.
Despite the achievements of modern medicine, tuberculosis remains one of the leading causes of mortality globally. The difficulties in differential diagnosis have particular relevance in the case of suspicion of tuberculosis with other granulomatous diseases. The most similar clinical and radiologic changes are sarcoidosis.
View Article and Find Full Text PDFLeishmania infantum infection modulates messenger RNA, microRNA and long non-coding RNA expression in human neutrophils in vitro.
PLoS Negl Trop Dis
July 2024
Department of Production and Animal Health, São Paulo State University (Unesp), School of Veterinary Medicine, Araçatuba, São Paulo, Brazil.
In the Americas, L. infantum (syn. chagasi) is the main cause of human visceral leishmaniasis.
View Article and Find Full Text PDFExplainable AI-driven model for gastrointestinal cancer classification.
Front Med (Lausanne)
April 2024
Department of Computer Science, King Abdulaziz University, Rabigh, Saudi Arabia.
Although the detection procedure has been shown to be highly effective, there are several obstacles to overcome in the usage of AI-assisted cancer cell detection in clinical settings. These issues stem mostly from the failure to identify the underlying processes. Because AI-assisted diagnosis does not offer a clear decision-making process, doctors are dubious about it.
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