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(pollen beetle) gastrointestinal disease experimentally reproduced in sheep.
Vet Pathol
January 2025
University of California, Davis, San Bernardino, CA.
Intoxication of sheep and cattle by recently occurred in Uruguay and Argentina in association with severe drought. Although the disease was experimentally reproduced in sheep in the 1970s, there is limited information on clinical and pathologic findings of sheep experimentally intoxicated by this beetle. Here, we described the clinical, gross, and microscopic findings in 3 sheep orally dosed with (treatment group, TG) and in 2 control sheep (control group, CG) dosed with distilled water.
View Article and Find Full Text PDFAcute stress triggers sex-dependent rapid alterations in the human small intestine microbiota composition.
Front Microbiol
January 2025
Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Background/aims: Digestive disorders of gut-brain interaction (DGBI) are very common, predominant in females, and usually associated with intestinal barrier dysfunction, dysbiosis, and stress. We previously found that females have increased susceptibility to intestinal barrier dysfunction in response to acute stress. However, whether this is associated with changes in the small bowel microbiota remains unknown.
View Article and Find Full Text PDFDistal ileal volvulus leading to intestinal obstruction: A case report.
Int J Surg Case Rep
January 2025
Department of Diagnostic Radiology, BP Koirala Institute of Health Sciences (BPKIHS), Nepal.
Introduction: Small bowel volvulus (SBV) involves the abnormal twisting of a small bowel loop around its mesenteric axis, often causing intestinal obstruction. It is rare in Western countries but accounts for up to 20-35 % of small bowel obstruction (SBO) cases in Asia, Africa, and the Middle East due to dietary and environmental factors. Non specific symptoms might lead to delayed diagnosis.
View Article and Find Full Text PDFSelect microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling.
iScience
February 2025
Department of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
The vagus nerve is proposed to enable communication between the gut microbiome and the brain, but activity-based evidence is lacking. We find that mice reared germ-free exhibit decreased vagal tone relative to colonized controls, which is reversed via microbiota restoration. Perfusing antibiotics into the small intestines of conventional mice, but not germ-free mice, acutely decreases vagal activity which is restored upon re-perfusion with intestinal filtrates from conventional, but not germ-free, mice.
View Article and Find Full Text PDFEffect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia after Running in the Heat.
Med Sci Sports Exerc
January 2025
Department of Health, Exercise, and Sports Sciences, University of New Mexico, Albuquerque, NM.
Purpose: To test the hypothesis that ibuprofen ingestion exacerbates markers of acute kidney injury (AKI), gastrointestinal (GI) injury, and endotoxemia after running in the heat.
Methods: Using a randomized double-blind crossover design, eleven physically active individuals (six women) ingested 600 mg of ibuprofen or placebo 12- and one-hour prior to running one-hour in a heated chamber (35 °C, 20%-60% R.H.
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