Objective: Naevus density in children depends both on constitutional factors (see below) and on previous (solar) UV exposure, which is a well-known risk factor for malignant melanoma. Secular trends of childhood UV exposure - e. g., due to intervention programmes - can be monitored by repeated, standardised cross-sectional studies assessing naevus density in children.
Methods: The 'CMONDE-Study (childhood monitoring of naevus density)' appears as a suitable instrument, introduced into the process of school enrollment for children of the years 1999 and 2000 in Göttingen.
Results: Analyses are based on 3883 children. Median age was 6.25 years, the proportion of girls 47 %. Median naevus density was 5.8/m(2), with an increase of density from 'Fitzpatrick skin type' IV to II, but marked decrease in type I. Similarly, naevus density increased with increasing lightness of hair colour, but was very low in red-haired individuals. While the number of freckles was also strongly associated with naevus density, the association between iris colour and skin darkness, respectively, was weak.
Conclusion: To meet the objective of continual monitoring, further comparative cross-sectional studies are needed.
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http://dx.doi.org/10.1055/s-2002-22314 | DOI Listing |
Unlabelled: Considering the similarity in clinical presentations of iris neoplasms of various origins, questions of their noninvasive diagnosis remain relevant. Optical coherence tomography angiography (OCT-A) is one of the imaging method that enables visualization of tumor vessels.
Purpose: This article examines the features of angioarchitecture, vascular network density, and perfusion density of iris melanoma and progressive iris nevus using OCT-A.
Br J Dermatol
November 2024
Department of Population Health, QIMR Berghofer Medical Research Institute, QLD, Australia.
Background: Cutaneous melanoma incidence varies consistently across body sites between men and women, but the underlying causes of these differences remain unclear. To date, no prospective studies have examined risk factors for melanoma separately for men and women according to body site.
Objectives: We aimed to examine the association between identified constitutional, genetic and environmental risk factors for invasive melanoma of different body sites among men and women.
J Am Acad Dermatol
November 2024
Department of Dermatology, University of California, Irvine, Irvine, California; Beckman Laser Institute, University of California, Irvine, Irvine, California. Electronic address:
Background: Port-Wine Birthmarks (PWB) are congenital capillary malformations requiring multiple treatments. Optical coherence tomography (OCT), a noninvasive imaging technique, characterizes vessels in cutaneous vascular lesions, including PWBs.
Objective: To assess variability in blood vessel characteristics within and between individual PWBs.
Curr Eye Res
June 2024
Mantis Photonics AB, Lund, Sweden.
Purpose: The prevalence of choroidal naevi is common and has been found to be up to 10%. Little is known regarding the optical properties of choroidal naevi. A novel hyperspectral eye fundus camera was used to investigate choroidal naevi's optical density spectra in the retina.
View Article and Find Full Text PDFClin Exp Dermatol
July 2024
Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shijingshan, Beijing, China.
Background: Congenital melanocytic naevi (CMN) are the result of aberrations in the mitogen-activated protein kinase signal transduction pathway. The risk of melanoma is the most important concern among patients with CMN because of its poor prognosis. However, as a result of the great variability between studies, the reported risk of melanoma varies considerably, making it difficult to provide reliable information.
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