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Paradoxical Increase in Body Mass Induced by Beta-Guanidinopropionic Acid in Juvenile Spontaneously Hypertensive Rats.
Cureus
November 2021
Cardiovascular Disease and Cardiovascular Population Health, Creatine Kinase Foundation, Amsterdam, NLD.
Background The adenosine triphosphate (ATP) regenerating enzyme creatine kinase (CK) is intimately involved in blood pressure generation. Consequently, the creatine transporter and CK inhibitor beta-guanidinopropionic acid (GPA) successfully reduced blood pressure in 16-week-old spontaneously hypertensive rats (SHR), but GPA may cause growth retardation in juvenile mammals. This report considers a serendipity observation of paradoxical growth increase after using GPA to prevent hypertension in three-week-old SHR.
View Article and Find Full Text PDFBeta-guanidinopropionic acid has age-specific effects on markers of health and function in mice.
Geroscience
June 2021
Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
AMP-activated protein kinase (AMPK) is a central regulator of both lifespan and health across multiple model organisms. β-Guanidinopropionic acid (GPA) is an endogenous AMPK activator previously shown to improve metabolic function in young and obese mice. In this study, we tested whether age of administration significantly affects the physiological outcomes of GPA administration in mice.
View Article and Find Full Text PDFCreatine kinase, energy reserve, and hypertension: from bench to bedside.
Ann Transl Med
August 2018
Department of Cardiovascular Disease, Creatine Kinase Foundation, Amsterdam, The Netherlands.
We hypothesized that human variation in the activity of the ATP regenerating enzyme creatine kinase (CK) activity affects hypertension and cardiovascular disease risk. CK is tightly bound close to ATP-utilizing enzymes including Ca-ATPase, myosin ATPase, and Na/K-ATPase, where it rapidly regenerates ATP from ADP, H, and phosphocreatine. Thus, relatively high CK was thought to enhance ATP-demanding processes including resistance artery contractility and sodium retention, and reduce ADP-dependent functions.
View Article and Find Full Text PDFCreatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm.
Hum Reprod
June 2018
Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.
Study Question: Why are many sperm required for successful fertilization of oocytes in vitro, even though fertilization occurs in vivo when only a few sperm reach the oocyte?
Summary Answer: Creatine produced in the ovary promotes efficient fertilization in vivo; however, in vitro, creatine is not contained in the in vitro fertilization (IVF) medium.
What Is Known Already: The IVF medium enables capacitation of sperm. However, the IVF medium does not fully mimic the in vivo environment during fertilization.
Creatine kinase inhibition lowers systemic arterial blood pressure in spontaneously hypertensive rats: a randomized controlled trial.
J Hypertens
December 2016
aDepartment of Vascular Medicine bLaboratory for Genetic and Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam cDepartment of Vascular Medicine and Pharmacology, Erasmus Medical Center, Rotterdam dDepartment of Obstetrics and Gynaecology and Reproductive Biology Laboratory eDepartment of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands fThe Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio, USA.
Article Synopsis
- Creatine kinase is linked to blood pressure regulation, as it helps generate ATP which is crucial for muscle contraction and sodium retention in the kidneys.
- In a study with hypertensive rats, researchers tested a creatine kinase inhibitor, beta-guanidinopropionic acid, over four weeks to see its effects on blood pressure.
- Results showed that inhibiting creatine kinase significantly lowered blood pressure, improved blood vessel dilation, and had a diuretic effect, suggesting it could be a new treatment option for hypertension.
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