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Agranulocytosis associated with lamotrigine in a patient with low-grade glioma. | LitMetric

Agranulocytosis associated with lamotrigine in a patient with low-grade glioma.

Epilepsia

Section of Hematology/Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA.

Published: February 2002

AI Article Synopsis

Article Abstract

Purpose: To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor.

Methods: A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously.

Results: After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved.

Conclusions: In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.

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Source
http://dx.doi.org/10.1046/j.1528-1157.2002.31801.xDOI Listing

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