AI Article Synopsis
- Bioactive lipids like sphingosine 1-phosphate (SPP) influence angiogenesis by affecting the migration of endothelial cells (ECs) and maintaining the integrity of EC layers.
- Extremely low serum and nanomolar concentrations of these lipids promote migration in human aortic smooth muscle cells (SMCs), while higher doses effectively inhibit SMC migration and block growth factor-induced movement.
- SPP activates a specific protein related to the PDGF receptor, suggesting that these lipids help regulate the movement of both ECs and SMCs during angiogenesis based on changing lipid gradients.
Article Abstract
The bioactive lipids sphingosine 1-phosphate (SPP), sphingosylphosphorylcholine, and lysophosphatidic acid play an important role in angiogenesis as a result of their effects on both the migration of endothelial cells (ECs) and the integrity of EC monolayers. Here we show that extremely low concentrations of serum and nanomolar concentrations of these biologically active lipids stimulate migration of human aortic smooth muscle cells (SMCs). However, at dosages most effective in promoting EC migration and in enhancing EC monolayer integrity, serum and SPP potently inhibited SMC migration; SPP also blocked the migration induced by protein growth factors. Treatment of SMCs with SPP induced transient phosphorylation of a 175- to 185-kDa protein corresponding to the PDGF receptor, indicating transactivation of this receptor. SPP and related lipids may play a key role in angiogenesis by coordinating the migration of both endothelial cells and vascular smooth muscle cells in response to the changing gradients of these bioactive lipid messengers.
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| http://dx.doi.org/10.1006/excr.2002.5472 | DOI Listing |
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