[Involvement of rabbit motor cortex neurons in the instrumental behavior before and after chronic ethanol consumption: a comparison with the limbic cortex].

The effect of acute administration is significantly more prominent in the limbic (cingulate) than in the motor cortex [9]. We proposed that the limbic cortex is more sensitive also to chronic ethanol treatment (CET). It was shown that morphology as well as neuronal activity of the limbic cortex changed greatly after the CET [7]. The missing link of testing the above proposition was a comparison of the obtained data with the results of the experimental study of CET influence on the motor cortex. Morphology of the anterolateral motor cortex and activity of its neurons in the instrumental food-acquisition behavior were studied in 6 male rabbits after CET (9 months). It was found that the limbic cortex was modified morphologically and functionally to a significantly greater extent than the motor cortex. We consider the fact that in the limbic cortex of a healthy individual there are many neurons, which for a while cease their discharges after the acute ethanol administration, to be among the most important reasons for this difference. Such-like repeated activity interruptions in the course of CET impair the performance of the systems incorporating these neurons. In such a way ethanol prevents all neurons, especially the mentioned ones, from receiving adequate metabolic supply that is necessary for their survival and functioning.