When dealing with some of primary prevention of alcoholism, the starting point is always a preliminary descriptive study of valueattitude systems of community groups, being one of the main prevention goals to modify certain guidelines and patterns of alcohol intake. This research aims at: a) Description of attitudes towards alcohol of 116 adolescents between 12 and 16 years in Córdoba City, belonging to middle class, white collar and qualified blue collar; b) Definition of relationships between adolescents' attitudes and social class; c) Determination, according to the social class, of favorable, unfavorable or neutral attitudes towards a program of prevention and control of alcoholism. A questionnaire with 49 uncomplete phrases first conceived for Chile and adapted to our milieu was used. General results show that middle class and nonqualified working class groups are the ones who most disapprove of and condemn alcohol abuse and, at the same time, avoid to a higher degree drinking alcohol. When alcohol intake in women is considered, the percentage is even higher. Groups belonging to middle classes think alcohol abuse is the result of sadness, anguish, and the like. For the qualified working classes, the causes are attending parties or meetings where others drink; there is a high percentage of answers showing compassion for alcoholics. Helping attitudes are higher in these groups, and more permissive and flexible attitudes are found. A favorable disposition towards prevention programs is registered for more than 55% of the total number of adolescents in this research.
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J Anal Toxicol
January 2025
Department of clinical pharmacology, St. Olavs University Hospital, Trondheim, Norway.
There is a growing interest for quantification of drugs in capillary blood. Phosphatidylethanol (PEth) is a biomarker for alcohol intake measured in whole blood, thus making it a candidate for capillary sampling. Our laboratory has been running a method for PEth quantification in venous blood since 2016 and we aimed to expand this method to also include capillary dried blood spot (DBS) samples.
View Article and Find Full Text PDFRisk Manag Healthc Policy
January 2025
Université Paris Cité, Inserm U1266, Institut de Psychiatrie et Neurosciences de Paris (IPNP), Team Vulnerability of Psychiatric and Addictive Disorders, Paris, France.
Purpose: Alcohol use is a leading risk factor for preventable death, injury, and disease globally. Low sensitivity to the effects of alcohol is influenced by genes and predicts risk for harmful alcohol use and alcohol use disorder (AUD). Alcohol induces effects partly by modulation of gamma-aminobutyric acid receptors type A (GABARs).
View Article and Find Full Text PDFJ Psychopharmacol
January 2025
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Background: More than 1 million people in the United States meet the criteria for cocaine use disorder (CUD), and over 19,000 people died from cocaine-related overdoses in 2020, but there are currently no FDA-approved medications for the treatment of CUD. Bupropion is an antidepressant currently prescribed to treat depression and nicotine addiction that acts by inhibiting norepinephrine and dopamine transporters.
Methods: In this study, we tested the effect of several doses of systemic bupropion on cocaine self-administration in male and female Wistar rats.
Rev Med Suisse
January 2025
Service de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.
This article presents the latest recommendations for the promotion of health and prevention. This article is primarily addressed to public health actors and stakeholders. The recommendations are contextualized to the local reality, based on Geneva-specific data from the longitudinal Specchio studywhich evaluates the health status of the Geneva population and its determinants.
View Article and Find Full Text PDFDrug Alcohol Depend
January 2025
Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:
Adolescence is a developmental period marked by significant alterations to brain neurobiology and behavior. Adolescent nicotine use disrupts developmental trajectories and increases vulnerability to maladaptive drug-taking in adulthood. The mesolimbic dopamine (DA) system, including the nucleus accumbens core (NAc), mediates the reinforcing effects of nicotine.
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