[Effects of aspirin standard therapy and chronotherapy on circadian organization of hemocoagulation in patients with insulin-dependent diabetes mellitus].

24-h profile of hemocoagulation was assessed in 30 patients with insulin-dependent diabetes mellitus type 1 aged 17-37 years. The patients were randomized into 2 groups, 15 patients each. Patients of group 1 received aspirin by conventional scheme: 125 mg 3 times a day for 16 days. Patients of group 2 received aspirin as preventive chronotherapy: once a day in a dose 125 mg for 16 days two hours before the acrophase of platelet aggregation rhythm--at 22 p.m. Parameters of plasmic and platelet hemostasis in blood samples were measured at 3.00, 7.00, 11.00 a.m., 15.00, 19.00, 23.00. The above chronobiological information was processed by Kosinor-analysis according to F. Halberg. Before the treatment, hypercoagulation with night rise as well as external and internal desynchronism of the hemostasis circadian rhythms were observed. Conventional aspirin treatment improved hemostasis but influenced acrophases minimally. Aspirin chronotherapy promoted normalization of circadian organization of hemocoagulation.