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mar Operon involved in multidrug resistance of Enterobacter aerogenes. | LitMetric
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mar Operon involved in multidrug resistance of Enterobacter aerogenes.

Renaud Chollet Claude Bollet Jacqueline Chevalier Monique Malléa Jean-Marie Pagès Anne Davin-Regli

Antimicrob Agents Chemother

Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 9606-EA 2197, Facultés de Médecine et Pharmacie, Université de la Méditerranée, 13385 Marseille Cedex 05, France.

Published: April 2002

We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127096PMC
http://dx.doi.org/10.1128/AAC.46.4.1093-1097.2002DOI Listing

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