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Rationale and design of the multicenter, national, randomized, open labeled phase III trial: allogeneic stem cell transplantation as a potential curative treatment for patients with relapsed or progressed multiple myeloma (AlloRelapseMM Study).
BMC Cancer
January 2025
Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Even though major improvements have been made in the treatment of myeloma, the majority of patients eventually relapse or progress. Patients with multiple myeloma who relapse after initial high-dose chemotherapy with autologous stem cells have a median progression free survival up to 2-3 years, depending on risk factors such as previous remission duration. In recent years, growing evidence has suggested that allogeneic stem cell transplantation could be a promising treatment option for patients with relapsed or progressed multiple myeloma.
View Article and Find Full Text PDFMicroRNAs Expression Profile in MN1-Altered Astroblastoma.
Biomedicines
January 2025
Department of Radiological, Oncological and Anatomo-Pathological Sciences, University Sapienza of Rome, 00161 Rome, Italy.
Background/objectives: Astroblastoma is a rare glial neoplasm more frequent in young female patients, with unclear clinical behaviors and outcomes. The diagnostic molecular alteration is a rearrangement of the Meningioma 1 () gene. MicroRNAs (miRNAs) are important gene expression regulators with strong implications in biological processes.
View Article and Find Full Text PDFIntergenerational Impacts of Historical Trauma on Contemporary Depression Symptoms Among Indigenous Communities.
J Am Acad Child Adolesc Psychiatry
January 2025
Johns Hopkins University, Duluth, Minnesota.
Introduction: Indigenous communities in the U.S. and Canada have endured generations of historical trauma.
View Article and Find Full Text PDFThe influence of land surface temperature on Ghana's climate variability and implications for sustainable development.
Sci Rep
January 2025
Department of Geography and Spatial Information Techniques, School of Civil and Environmental Engineering and Geography Science, Ningbo University, Ningbo, 315211, China.
Climate change poses significant global challenges, especially in the West African sub-region, with high temperature and precipitation patterns variability, threatening socio-economic stability and ecosystem health. While global factors such as greenhouse gases and oceanic circulations shape regional climates, this study focuses on the understudied role of local climatic variables in influencing near-surface air temperature (NST) in Ghana from 1981 to 2020. Based on ground observations, our findings reveal significant correlations between land surface temperature (LST) and NST before and after the identified breakpoint year of 2001.
View Article and Find Full Text PDFHow do we co-produce care planning with people living with dementia: A scoping review.
Int J Nurs Stud
January 2025
Department of Psychology, School of Mental Health & Psychological Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Background: Legislation, policy and clinical guidance champions the values of co-production in good care planning; however, it is unclear what kind of information is available in the literature about how concepts of co-production have been applied in practice to care planning from the perspective of people living with dementia and their carers as experts-by-experience. A scoping review was conducted to map the current evidence addressing care planning co-production practice from the perspectives of people living with dementia and their carers across various settings of dementia care.
Methods: A two-phase process was employed.
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