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LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.
Open Biol
December 2023
Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain.
Adult planarians can regenerate the gut, eyes and even a functional brain. Proper identity and patterning of the newly formed structures require signals that guide and commit their adult stem cells. During embryogenesis, LIM-homeodomain (LIM-HD) transcription factors act in a combinatorial 'LIM code' to control cell fate determination and differentiation.
View Article and Find Full Text PDFThe multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5.
Stem Cell Reports
November 2023
Gladstone Institutes, San Francisco, CA, USA; Roddenberry Center for Stem Cell Biology at Gladstone, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, UCSF School of Medicine, San Francisco, CA, USA. Electronic address:
Congenital heart disease often arises from perturbations of transcription factors (TFs) that guide cardiac development. ISLET1 (ISL1) is a TF that influences early cardiac cell fate, as well as differentiation of other cell types including motor neuron progenitors (MNPs) and pancreatic islet cells. While lineage specificity of ISL1 function is likely achieved through combinatorial interactions, its essential cardiac interacting partners are unknown.
View Article and Find Full Text PDF, , , , , , , and Genetic Variants in Patients with Premature Ovarian Insufficiency in a Mexican Cohort.
Genes (Basel)
March 2022
Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Ciudad de México 14080, Mexico.
Premature ovarian insufficiency (POI) is one of the main causes of female premature infertility. POI is a genetically heterogeneous disorder with a complex molecular etiology; as such, the genetic causes remain unknown in the majority of patients. Therefore, this study aimed to identify mutations and characterize the associated molecular contribution of gonadogenesis-determinant genes to POI.
View Article and Find Full Text PDFDeep conservation of the enhancer regulatory code in animals.
Science
November 2020
School of Biological Sciences, University of Queensland, Brisbane, Australia.
Article Synopsis
- Enhancers are DNA regulatory sequences that help define cell identity during development in animals, while transcription factors (TFs) interact with these enhancers.
- Researchers used enhancers from an evolutionarily distant marine sponge to manipulate zebrafish and mouse development, revealing shared TF binding patterns.
- The study suggests a highly conserved and adaptable genomic regulatory system that has been utilized across different species to form specific gene regulatory networks.
[Discovery and functional analysis of a novel ISL1 variant associated with congenital heart defect].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
September 2020
Department of Pediatrics, Huashan North Hospital, Fudan University, Shanghai 201907, China.
Objective: To analyze variation of ISL1 gene and explore its functional characteristics in relation with congenital heart defect (CHD).
Methods: Clinical data and peripheral blood samples of 194 CHD patients and 232 healthy controls were collected for the extraction of genomic DNA. The coding exons and flanking intronic regions of the ISL1 gene were sequenced.
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