AI Article Synopsis
- Fluorofur (FT) gradually breaks down in the body, releasing free 5-FU more slowly than if 5-FU were given directly.
- The presence of 5-FU from FT lasts longer in the body, potentially enhancing its effectiveness.
- FT leads to lower concentrations of 5-FU, which may result in less toxicity compared to direct 5-FU treatment, making it a more effective option for treating malignant tumors.
Article Abstract
Fluorofur (FT) is slowly splitted in tissues releasing free 5-FU. The duration of stay in the organism of 5-FU formed from FT is longer than that of 5-FU administered solely. Moreover, FT does not result in the formation of such high 5-FU concentrations, as observed while using 5-FU itself. It seems to account for an insignificant toxicity of FT and its greater efficacy in treatment of malignant tumors.
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