Along with the description of the architectonics of elastic fibres in normal cervicovaginal tissues the kinetics of their changes was followed in precancerous conditions and cancer of the cervix. It was found that during the process of growth and development of precancerous lesions and cancer elastic fibres would undergo a number of gradually increasing changes from surface, reversible to profound, irreversible with their ultimate total destruction.
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Sci Rep
January 2025
Jun Shi Department of Ultrasound, The First Hospital of Hebei Medical University, Shijiazhuang City, 050031, Hebei Province, China.
Transrectal shear wave elastography (T-SWE) can be used non-invasively to diagnose prostate cancer (PCa) and benign prostatic hyperplasia (BPH). The prostate tissue can be viewed as an ellipsoidal sphere with viscoelastic characterization. Linear elastic model has been used to characterize soft tissues, and the simplification of partial characterization provides incomplete information.
View Article and Find Full Text PDFAm J Physiol Lung Cell Mol Physiol
January 2025
Department of Bioengineering, University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO, USA.
Lung progenitor (LP) cells identified by the expression of transcription factor NK2 homeobox 1 (NKX2.1) are essential for development of all lung epithelial cell types and hold tremendous potential for pulmonary research and translational regenerative medicine applications. Here we present engineered hydrogels as a promising alternative to the naturally derived materials that are often used to differentiate human induced pluripotent stem cells (iPSCs) into LP cells.
View Article and Find Full Text PDFHand Surg Rehabil
January 2025
Physical Therapy and Rehabilitation Unit, Policlinico di Modena, Modena, Italy; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
A non-invasive thermoplastic orthosis combined with targeted exercise effectively addresses proximal interphalangeal joint (PIPj) stiffness. Stabilizing the metacarpophalangeal joint at 60 ° enables optimal torque transfer, improving flexion and correcting compensatory patterns. Posture maintenance prevents elastic recoil,enhancing tissue elongation.
View Article and Find Full Text PDFAbdom Radiol (NY)
January 2025
AGH University of Krakow, Krakow, Poland.
Purpose: Shear wave elastography (SWE) provides a means for adding information about the mechanical properties of tissues to a diagnostic ultrasound examination. It is important to understand the physics and methods by which the measurements are made to aid interpretation of the results as they relate to disease processes.
Methods: The components of how ultrasound is used to generate shear waves and make measurements of the induced motion are reviewed.
Cell Rep Med
January 2025
Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China; Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China; School of Basic Medical Science, Guangzhou Medical University, Guangzhou, Guangdong 510182, P.R. China. Electronic address:
C-C chemokine receptor type 2 (CCR2) cardiac-resident macrophages (CCR2 cRMs) are known to promote cardiac repair after myocardial infarction (MI). However, the substantial depletion and slow recovery of CCR2 cRMs pose significant barriers in cardiac recovery. Here, we construct a functional conductive cardiac patch (CCP) that can provide exogenously elastic conductive microenvironment and induce endogenously reparative microenvironment mediated by CCR2 cRMs for MI repair.
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