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Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex.
Biomedicines
December 2024
Blue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, 1202 Geneva, Switzerland.
The cerebral microvasculature forms a dense network of interconnected blood vessels where flow is modulated partly by astrocytes. Increased neuronal activity stimulates astrocytes to release vasoactive substances at the endfeet, altering the diameters of connected vessels. Our study simulated the coupling between blood flow variations and vessel diameter changes driven by astrocytic activity in the rat somatosensory cortex.
View Article and Find Full Text PDFMorphology and Immunoexpression of Selenoproteins in Term Placenta of Alpaca () from the Peruvian Andes.
Biology (Basel)
January 2025
Department of Animal Anatomy, University of Marilia, Marília 17525-902, São Paulo, Brazil.
South American camelids inhabit high-altitude environments characterized by hypoxia, influencing embryonic, fetal, and placental development. This study examined the term placenta morphology of alpacas (, N = 12) and the immunoexpression of antioxidant selenoproteins (SP). We hypothesize that the placenta of alpacas, adapted to high altitudes, has characteristics with other species also adapted to altitude.
View Article and Find Full Text PDFFabricating a stable interface of tetracoordinated-phosphorus and framework Al within P-doping ZSM-5 zeolite for catalytic methanol-to-propylene reaction.
J Colloid Interface Sci
January 2025
Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, PR China; Yunnan Provincial Key Laboratory of Energy Saving in Phosphorus Chemical Engineering and New Phosphorus Materials, Kunming 650500, PR China. Electronic address:
Phosphorus (P)-doping H-ZSM-5 zeolites, which is crucial for industrial applications, aim to adjust both acidity and framework stability while optimizing product distribution in heterogeneous catalysis. Nonetheless, current phosphating methods often suffer from inadequate phosphorus dispersion and unclear interfacial interactions with framework aluminum (Al). In this work, P-doping ZSM-5 zeolites were successfully one-step prepared by using tributylphosphine served as an organophosphorus precursor, assisting by density functional theory calculations.
View Article and Find Full Text PDFAssessing fluid responsiveness by using functional hemodynamic tests in critically ill patients: a narrative review and a profile-based clinical guide.
J Clin Monit Comput
January 2025
IRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano - Milan, 20089, Italy.
Fluids are given with the purpose of increasing cardiac output (CO), but approximately only 50% of critically ill patients are fluid responders. Since the effect of a fluid bolus is time-sensitive, it diminuish within few hours, following the initial fluid resuscitation. Several functional hemodynamic tests (FHTs), consisting of maneuvers affecting heart-lung interactions, have been conceived to discriminate fluid responders from non-responders.
View Article and Find Full Text PDFPerifoveal vascular anomalous complex and telangiectatic capillaries: An overview of two entities potentially sharing a common pathophysiology.
Surv Ophthalmol
January 2025
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Division of head and neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address:
Focal capillary ectasia in the macular region can manifest in distinct clinical scenarios, which can be categorized into 2 main entities: perifoveal vascular anomalous complex (PVAC) and telangiectatic capillaries (TelCaps). PVAC represents a primary, idiopathic condition, whereas TelCaps occur secondary to underlying vascular disorders, including diabetic macular edema and retinal vein occlusion. We provide a comprehensive analysis of these 2 entities, encompassing their clinical presentations, multimodal imaging findings, histological evidence, and differential diagnosis from other retinal microvascular abnormalities, such as Type 1 macular telangiectasia, adult-onset Coats disease, Type 3 macular neovascularization in age-related macular degeneration, and retinal arterial macroaneurysms.
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