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Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium.
Brain Behav Immun Health
February 2025
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Delirium is a highly prevalent neuropsychiatric syndrome characterised by acute and fluctuating impairments in attention and cognition. Mechanisms driving delirium are poorly understood but it has been suggested that blood cytokines and chemokines cross the blood brain barrier during delirium, directly impairing brain function. It is not known whether these molecules reach higher brain levels when the blood cerebrospinal fluid barrier (BCSFB) is impaired.
View Article and Find Full Text PDFStudents perspectives on the development and deployment of an AI-enabled service robot in long-term care.
J Rehabil Assist Technol Eng
January 2025
School of Nursing, University of British Columbia, Vancouver, BC, Canada.
The need for Artificial Intelligence (AI) in gerontology education is underscored by the potential benefits it offers in addressing loneliness and supporting social connection among older adults in long-term care (LTC) homes. While the workforce in LTC is often overburdened, AI-enabled service robots present possible solutions to enhance residents' quality of life. However, the incorporation of AI and service robots in current gerontology curricula is lacking, and the views of students on this subject remain largely unexamined.
View Article and Find Full Text PDFTherapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis.
Front Aging Neurosci
January 2025
Department of Geriatric Medicine, Quzhou People's Hospital, Quzhou, China.
Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing a key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) in a zebrafish AD model.
View Article and Find Full Text PDF[New Directions in Elderly Care Workforce Nurturing: Cross-Professional Collaboration From a Social Co-Care Perspective, Drawing Insights From Japan's Elderly Care Experience].
Hu Li Za Zhi
February 2025
Graduate Institute of Gerontology and Health Care Management, Chang Gung University of Science and Technology, Taiwan, ROC.
The increasingly severe issue of societal aging worldwide has prompted the reevaluation of elderly-care strategies and related workforce development. This paper was developed to explore new directions in elderly care workforce development from the perspective of social co-care. The current state and challenges of elderly care personnel in Taiwan are analyzed, emphasizing the importance of cross-professional collaboration to enhancing elderly care quality.
View Article and Find Full Text PDFAnalysis and Comparison of Lipids in -Fermented Cheese from Different Ripening Periods Based on UHPLC-QTRAP MS Quantitative Lipidomics.
J Agric Food Chem
January 2025
Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beijing 100048, China.
-fermented cheese (MC) is a new cheese product that undergoes a multistrain fermentation process, which results in unique flavor qualities. Lipid metabolism plays an important role in the flavor formation of MC. To clarify the lipid composition of MC and the changes in lipid composition at four ripening periods, this study resolved the lipid profiles of MC by using UHPLC-QTRAP MS.
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