A 36-year-old woman suffered from steroid-responsive relapsing myelitis associated with hypocomplementemia, thrombocytopenia, and anti-cardiolipin antibody. At the second attack of paraplegia, neck flexion in a supine position induced uncomfortable dysesthesia radiating into the ulnar side of the bilateral forearms. Both truncal and neck flexion resulted in painful dysesthesia down into both lower limbs also. Cervical MRI showed 2 gadolinium-enhanced dorsal-dominant lesions in the spinal cord at C 5/6 and C 6/7 disc levels. Enhancement of Lhermitte sign by truncal flexion might be useful to detect multiple lesions in the dorsal column.
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MOG IgG antibody positivity from laboratory to clinical practice: A real world experience.
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Department of Pediatric Cardiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidhyapeetham, Ponekkara PO, Kochi 682041, Kerala, India.
Background And Objectives: Myelin oligodendrocyte glycoprotein (MOG) associated disease (MOGAD) is an antibody-mediated inflammatory demyelinating disorder of the CNS with varied presentations like optic neuritis (ON), transverse myelitis, and cortical encephalitis. This study aims to highlight the significance of low MOG IgG antibody positivity and its diagnostic implications in a real-world cohort.
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MOG-IgG is rare in AQP4-IgG seronegative NMO phenotype in Brazil.
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CIEM MS Research Center, Federal University of Minas Gerais Medical School, Belo Horizonte, MG, Brazil.
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View Article and Find Full Text PDFQuantitative Contribution of Clinical Attacks to Residual Disability in Patients With AQP4-Antibody Neuromyelitis Optica Spectrum Disorder.
Neurology
January 2025
From the Nuffield Department of Clinical Neurosciences (B.C., A.F., R.G., M.I.S.L., J.P.), Oxford University Hospitals, United Kingdom; Department of Neurology (B.C.), Tongji Hospital of Tongji Medical College, Huazhong University of Science of Technology, Wuhan, China; University Hospitals Sussex National Health Service Foundation Trust (S.A.C.), Brighton; Centre for Preventive Neurology (R.D.), Wolfson Institute of Population Health, Queen Mary University of London; Queen Square Multiple Sclerosis Centre (Y.H.), UCL Institute of Neurology, Faculty of Brain Sciences, University College London; Department of Paediatric Neurology (Y.H.), Great Ormond Street Hospital for Children, London; Department of Neurology (C. Halfpenny), University Hospital Southampton NHS Foundation Trust; Department of Neurology (C. Hemingway), Great Ormond Street Hospital for Children, London and Institute of Neurology; Department of Neurology (J.C.H.), University of Plymouth Faculty of Health and University Hospitals; Department of Ophthalmology (E.O.S.), King's College Hospital NHS Foundation Trust, London; Department of Neurology (W.R.), St George's University Hospitals NHS Foundation Trust, London; Department of Neurology (R.J.M.), Gloucestershire Hospitals National Health Service Foundation Trust; Department of Neurology (V.W.), King's College Hospital NHS Foundation Trust, London; Department of Neurology (V.W.), Guy's and St Thomas' National Health Service Foundation Trust, London; Department of Paediatric Neurology (S.R.), John Radcliffe Hospital, Oxford; and Neurology Department (R.G.), Wexham Park Hospital, Frimley Foundation Health Trust, Slough, United Kingdom.
Article Synopsis
- The study investigates how clinical attacks contribute to ongoing disability in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD).
- A total of 165 patients were analyzed using disability scores recorded after at least six months post-attack, with findings showing a significant increase in disability scores correlating with the number and type of relapses.
- Results indicated that specific relapse types, particularly the combination of transverse myelitis and optic neuritis, had the most substantial impact on increasing residual disability.
New-Onset Multiple Sclerosis in Pregnancy: Diagnostic Approaches and Treatment Dilemmas.
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November 2024
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Multiple sclerosis (MS) is an autoimmune disease of the CNS affecting the brain, spinal cord, and optic nerves. Research consistently shows that relapse rates in MS decrease during pregnancy, particularly in the third trimester. However, these rates increase postpartum, especially within the first three months after delivery, returning to prepregnancy levels.
View Article and Find Full Text PDFDisease characteristics of NMOSD and their relationship with disease burden: Observations from a large single-center cohort.
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December 2024
Division of Multiple Sclerosis and Neuroimmunology Department of Neurology, McGovern Medical School (UT Health), University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address:
Objective: To assess the demographic, clinical, and outcome data in patients with NMOSD across a single-center adult cohort and find out associations, if any, with the disease burden.
Background: Neuromyelitis Optica spectrum disorder is an autoimmune condition with unpredictable course and relapses. The clinical and economic burden of NMOSD has been studied less.
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