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Machine learning Nomogram for Predicting endometrial lesions after tamoxifen therapy in breast Cancer patients.
Sci Rep
January 2025
Department of Obstetrics and Gynecology, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
Objective Endometrial lesions are a frequent complication following breast cancer, and current diagnostic tools have limitations. This study aims to develop a machine learning-based nomogram model for predicting the early detection of endometrial lesions in patients. The model is designed to assess risk and facilitate individualized treatment strategies for premenopausal breast cancer patients.
View Article and Find Full Text PDFIs a Training Program in Pediatric Abdominal Ultrasonography Necessary for Pediatricians?
Pediatr Gastroenterol Hepatol Nutr
November 2024
Department of Pediatrics, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea.
Despite being an essential specialty, pediatrics in South Korea faces the threat of collapse. While the declining birth rate is an important contributor to the decrease in the pediatric population, a more critical issue lies in the dysfunctional healthcare system. Primary care pediatricians are troubled by the lack of patients, whereas tertiary care specialists are concerned about the shortage of doctors.
View Article and Find Full Text PDFREGULATOR OF FATTY ACID SYNTHESIS proteins regulate de novo fatty acid synthesis by modulating hetACCase distribution.
Plant Cell
December 2024
State Key Laboratory of Tree Genetics and Breeding, Co-Innovation Center for Sustainable Forestry in Southern China, Jiangsu Key Laboratory for Poplar Germplasm Enhancement and Variety Improvement, Nanjing Forestry University, Nanjing 210037, China.
Article Synopsis
- In plants, hetACCase is crucial for starting fatty acid synthesis by producing malonyl-CoA, with its activity tightly regulated depending on the plant's needs.
- A coexpression analysis in Arabidopsis identified the gene REGULATOR OF FATTY ACID SYNTHESIS 1 (RFS1), which interacts with CARBOXYLTRANSFERASE INTERACTOR 1 (CTI1) and plays a role in regulating hetACCase.
- Knockout experiments showed that loss of RFS genes increases hetACCase activity and fatty acid content in plants, suggesting a potential strategy for breeding plants with higher oil yields.
Challenges for the legislation enabling egg donation in Switzerland.
Med Law Int
September 2024
Department of Philosophy and Moral Sciences, Bioethics Institute Ghent, Ghent University, Belgium.
Article Synopsis
- Switzerland has had a long-standing ban on egg donation in medically assisted reproduction, despite recent legal changes for other reproductive practices.
- The discussion around lifting the ban is gaining traction in Swiss academia and politics, indicating potential changes ahead.
- Key regulatory issues that need addressing include age limits for donors and the management of egg sharing once donation becomes legal.
A management algorithm for idiopathic intracranial hypertension in skull base meningoencephaloceles.
J Neurosurg
September 2024
1Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine, Cleveland.
Article Synopsis
- The study evaluated an algorithm designed for diagnosing and managing idiopathic intracranial hypertension (IIH) in patients who had surgery for skull base meningoencephaloceles and experienced spontaneous cerebrospinal fluid (sCSF) leaks.
- The researchers reviewed records from 80 patients treated between 2014 and 2021, measuring their opening pressure (OP) and categorizing them into high, intermediate, or low-risk groups based on the OP.
- The findings revealed a VPS rate of 15%, with low recurrence rates for acute (3.8%) and remote CSF leaks (3.8%), highlighting the effectiveness of the proposed management strategy in understanding CSF dynamics in these patients.*
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