A 9-year-old girl who had ostium secundum atrial septal defect (ASD) and hereditary spherocytosis (HS) is described. The patient had a history of splenectomy for HS and underwent repair of the ASD under cardiopulmonary bypass (CPB), however, no significant or persistent hemolysis was observed during and after CPB. Only 10 patients with HS who underwent cardiac operations using CPB have been reported. The case is presented due to its rarity.
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