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Anti-Pythium insidiosum activity of three novel triazole compounds: synthesis, pharmacokinetic and toxicological parameters.
Braz J Microbiol
December 2024
Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Pythiosis, caused by Pythium insidiosum, is an infectious and non-transmissible disease affecting horses, dogs, and humans, with no effective drug treatment available. Triazoles are compounds of interest for their potential pharmacological properties against fungi and bacteria. In this study, we synthesized three new triazole compounds (C1, C2, and C3) to assess their in vitro activities against P.
View Article and Find Full Text PDFOptimal thresholds and key parameters for predicting influenza A virus transmission events in ferrets.
Npj Viruses
December 2024
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA USA.
Although assessments of influenza A virus transmissibility in the ferret model play a critical role in pandemic risk evaluations, few studies have investigated which virological data collected from virus-inoculated animals are most predictive of subsequent virus transmission to naïve contacts. We compiled viral titer data from >475 ferrets inoculated with 97 contemporary IAV (including high- and low-pathogenicity avian, swine-origin, and human viruses of multiple HA subtypes) that served as donors for assessments of virus transmission in the presence of direct contact (DCT) or via respiratory droplets (RDT). A diversity of molecular determinants, clinical parameters, and infectious titer measurements and derived quantities were examined to identify which metrics were most statistically supported with transmission outcome.
View Article and Find Full Text PDFFrom iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements with Vitamin C and Retinoic Acid in Diabetes Research.
Int J Mol Sci
September 2024
Center of Biomedical Investigation (CIBUS), Universidad de La Sabana, Chia 250008, Colombia.
Article Synopsis
- - Diabetes mellitus leads to various complications, but researchers are exploring the creation of pancreatic β-like cells (PβLCs) from induced pluripotent stem cells (iPSCs) as a potential treatment.
- - Current methods for differentiating iPSCs into pancreatic β cells aim to mimic natural pancreatic development using specific combinations of cytokines and small molecules to activate necessary signaling pathways.
- - This study presents a new protocol that effectively produces PβLCs with essential characteristics of pancreatic β cells, including insulin secretion and the expression of important markers, enhanced by the addition of vitamin C and retinoic acid during differentiation.
Ankle-brachial index and carotid ultrasound as surrogates for coronary artery disease diagnosis.
J Clin Ultrasound
November 2024
Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Introduction: Cardiovascular disease represents the foremost cause of death among chronic and non-transmissible diseases. Diagnostic tools commonly used for peripheral and carotid atherosclerosis, such as ankle-brachial index (ABI) and carotid ultrasonography (CU), may contribute as surrogates for the diagnosis of coronary arterial disease (CAD).
Material And Methods: We report a cross-sectional study of 50 patients referred to elective invasive coronary angiography (ICA).
Mass vaccination with reassortment-impaired live H9N2 avian influenza vaccine.
NPJ Vaccines
August 2024
Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Avian influenza poses a severe threat to poultry production and global food security, prompting the development of vaccination programs in numerous countries. Modified live virus (MLV) vaccines, with their potential for mass application, offer a distinct advantage over existing options. However, concerns surrounding reversion, recombination, and unintended transmission have hindered the progress of MLV development for avian influenza in poultry.
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