Background: The study assessed the incidence of pathologic gastroesophageal reflux in children with obstructive bronchitis and analyzed the correlation of pHmetric parameters with the incidence of obstructive bronchitis according to age groups.
Material/methods: 109 children aged from 4 months to 17 years with the history of at least two documented incidents of obstructive bronchitis during the period of one year were examined. Each patient underwent 24h esophageal pHmetry. The analyzed patients were divided into 3 age groups: I - 4 months-2 years, II - 3-9 years, III - 10-17 years; each of the obtained groups was divided into 2 subgroups according to the frequency of obstructive bronchitis (a - 2-4 times a year and b - over 4 times a year).
Results: Gastroesophageal reflux was diagnosed on the basis of pHmetry in 62.4% of patients. It was demonstrated in own material that gastroesophageal reflux is more frequent in boys (64.7%) than in girls (35.3%). Comparison of pHmetric parameters in children suffering from obstructive bronchitis more and less frequently did not demonstrate higher pHmetric parameters in children with more frequent occurrence of obstructive bronchitis in any of the age groups. Although gastroesophageal reflux occurred frequently in children with obstructive bronchitis, no proportional correlation was found between the pHmetric parameters and frequency of obstructive bronchitis
Conclusions: Esophageal pHmetry should be performed in children with obstructive bronchitis in order to confirm or exclude gastroesophageal reflux as a cause of recurrent obstructive bronchitis.
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BMJ Open Respir Res
January 2025
CHU de Bordeaux, Bordeaux, France.
Background: Chronic obstructive pulmonary disease (COPD) is a common treatable disease often diagnosed in patients with risk factors after a prolonged period with suggestive symptoms. Our qualitative study aimed to identify barriers to establishing diagnosis in the natural history of this condition.
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PLoS Med
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Clinical Epidemiology Unit, Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden.
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Am Fam Physician
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University of Kansas Medical Center, Kansas City.
Acute rhinosinusitis causes more than 30 million patients to seek health care per year in the United States. Respiratory tract infections, including bronchitis and sinusitis, account for 75% of outpatient antibiotic prescriptions in primary care. Sinusitis is a clinical diagnosis; the challenge lies in distinguishing between the symptoms of bacterial and viral sinusitis.
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Department of Pediatrics, Zhejiang University School of Medicine Second Affiliated Hospital Jiashan Branch, the First People's Hospital of Jiashan, Jiashan, Zhejiang, 314100, People's Republic of China.
Although infection with is generally self-limited, it may cause refractory or life-threatening pneumonia with pulmonary or extrapulmonary complications. Necrotizing bronchitis is a rare condition with a high mortality rate. The present report describes a patient with mycoplasma pneumonia and necrotizing bronchitis that caused airway obstruction.
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Research Unit of Biomedicine and Internal Medicine, University of Oulu, 902 20 Oulu, Finland.
Mucins 5AC (MUC5AC) and 5B (MUC5B) are the major mucins providing the organizing framework for the airway's mucus gel. We retrieved bronchial mucosal biopsies and bronchial wash (BW) samples through bronchoscopy from patients with chronic obstructive pulmonary disease ( = 38), healthy never-smokers ( = 40), and smokers with normal lung function ( = 40). The expression of MUC5AC and MUC5B was assessed immunohistochemically.
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