One hundred and forty-four cases of histologically confirmed colorectal cancer in patients managed at the Jos University Teaching Hospital (JUTH) over a 10 year period from January, 1989 to January, 1999 is discussed with special consideration to incidence, distribution and unfavourable prognosis. Altogether, 144 patients were treated for colorectal carcinoma. Eighty-seven were males while fifty-seven were females, giving a male to female ratio of 1.51:1. The mean age was 44.3 years. The commonest clinical presenting features were weight loss, bloody mucoid diarrhoea, anorectal mass, anaemia, low-back pain and constipation/increased noise in the abdomen, present for not less than 3 months. The rectum and rectosigmoid junction were the commonly affected sites. All, except four patients, had advanced disease at first presentation. Treatment was basically palliative with only 43.5 percent of those offered such treatment alive at 6 months while 25 percent had died. Prognosis is unfavourable. Though, predisposing factors are not clear, promotion of educational programme highlighting the dangers of concealing chronic large bowel symptoms and screening efforts will most probably reduce morbidity and mortality rates associated with this condition.
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PLoS One
January 2025
Department of Computer Science, Faculty of Computing, Federal University of Lafia, Lafia, Nasarawa State, Nigeria.
Eur Radiol
January 2025
Department of Radiology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Objectives: To analyze the CT imaging features of extranodal natural killer/T (NK/T)-cell lymphoma, nasal type (ENKTCL-NT) involving the gastrointestinal tract (GI), and to compare them with those of Crohn's disease (CD) and diffuse large B-cell lymphoma (DLBCL).
Materials And Methods: Data were retrospectively collected from 17 patients diagnosed with GI ENKTCL-NT, 68 patients with CD, and 47 patients with DLBCL. The CT findings of ENKTCL-NT were analyzed and compared with those of CD and DLBCL.
Eur J Clin Invest
January 2025
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Background: Several studies have investigated the association between Helicobacter pylori colonization and gastrointestinal malignancies. However, inconsistent results have been found, leaving no clear consensus.
Materials And Methods: Umbrella review of meta-analyses of observational studies aiming to understand the association between Helicobacter pylori colonization and gastrointestinal cancers in humans.
Int J Gynecol Cancer
January 2025
Helsinki University Hospital and University of Helsinki, Department of Obstetrics and Gynecology, Helsinki, Finland; University of Helsinki, Faculty of Medicine, Helsinki University Hospital and Research Program in Applied Tumor Genomics, Department of Pathology, Helsinki, Finland.
Objective: Endometrial carcinomas with mismatch repair deficiency (MMRd) and no specific molecular profile (NSMP) are considered to have intermediate prognoses. However, potential prognostic differences between these molecular subgroups remain unclear due to the lack of standardized control for clinicopathologic factors. This study aims to evaluate outcomes of MMRd and NSMP endometrial carcinomas across guideline-based clinicopathologic risk groups.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, People's Republic of China.
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