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Bilevel positive airway pressure ventilation to prevent hypoxaemia during gastroscopy under sedation in patients at risk of hypoxaemia: study protocol for a prospective randomised controlled trial.
BMJ Open
March 2025
Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Introduction: During sedation for gastroscopy, hypoxaemia represents the most common adverse event. The objective of this trial is to assess the efficacy and safety of bilevel positive airway pressure (BPAP) for the prevention of hypoxaemia, in comparison with nasal cannula oxygen therapy, among patients predisposed to hypoxaemia during sedation for gastroscopy.
Methods And Analysis: This randomised controlled trial (RCT) will include 616 patients at risk of hypoxaemia when undergoing gastroscopy, including those with advanced age, frailty, American Society of Anesthesiologists grades III-IV, obesity, obstructive sleep apnoea-hypopnoea syndrome, cardiac disease, respiratory disease and diabetes.
Neoantigen-based mRNA vaccine exhibits superior anti-tumor activity compared to synthetic long peptides in an in vivo lung carcinoma model.
Cancer Immunol Immunother
March 2025
Medical Genetics Institute, Ho Chi Minh City, Vietnam.
Neoantigen vaccines hold great promise in cancer immunotherapy, but the comparative efficacy of different vaccine platforms, particularly in the context of tumor burden (TB), remains insufficiently studied. In this research, we evaluated the safety and therapeutic efficacy of synthetic long peptide and mRNA-based vaccines, both designed to target identical neoantigens across different Lewis Lung Carcinoma (LLC) tumor burdens. We employed the LLC syngeneic mouse model, a widely used preclinical model for aggressive and immunosuppressive tumors.
View Article and Find Full Text PDFBackground: Anxiety is one of the most common factors that prevent people from going to a dentist. Therefore, finding a solution to better control stress has been an important issue in recent studies. Lemongrass positively affects the prevention of dental anxiety.
View Article and Find Full Text PDFDecoding different oxidative stress pathways in periodontitis: a comparative review of mechanisms of traditional tobacco smoke and electronic smoke aerosol.
Arch Toxicol
March 2025
Department of Pediatric and Preventive Dentistry, School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, 030001, China.
Tobacco smoking involves the use of devices such as pipes, cigars, or cigarettes to inhale and exhale smoke from burning tobacco leaves, primarily to ingest nicotine and other substances. The impact of oxidative stress from smoking on periodontitis and its underlying mechanisms remains poorly understood. Previous research has shown that smoking activates oxidative stress responses, generating harmful oxidative substances and free radicals that induce periodontitis.
View Article and Find Full Text PDFSupratherapeutic Inhaled Corticosteroid Use in Patients Initiating on Biologic Therapies for Severe Asthma: A Nationwide Cohort Study.
Lung
March 2025
Department of Respiratory Medicine, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.
Background: In severe asthma, intensive ("supratherapeutic") doses of inhaled corticosteroids (ICS) are often used. The prevalence of supratherapeutic ICS use and its impact on corticosteroid-related comorbidities is poorly understood. We aimed to describe the prevalence of supratherapeutic ICS use in severe asthma, its relation to corticosteroid-related comorbidities, and changes in prescribed and redeemed ICS dose after 12 months of biologic therapy.
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