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Opioid reward and deep brain stimulation of the lateral hypothalamic area.
Vitam Horm
January 2025
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Opioid use disorder (OUD) is considered a global health issue that affects various aspects of patients' lives and poses a considerable burden on society. Due to the high prevalence of remissions and relapses, novel therapeutic approaches are required to manage OUD. Deep brain stimulation (DBS) is one of the most promising clinical breakthroughs in translational neuroscience.
View Article and Find Full Text PDFMedial collateral ligament ganglion cyst: a rare cause of medial knee pain.
BMJ Case Rep
January 2025
Department of Trauma and Orthopaedics, Royal Free London NHS Foundation Trust, London, UK.
Ganglion cysts are commonly found in areas of constant mechanical stress such as the joints and tendons of the wrist or hand as well as the anterior aspect of the ankle. In the knee, parameniscal cysts are often encountered secondary to meniscal tears or articular degeneration. Intra-articular ganglion cysts are uncommon and often arise from the cruciate ligaments and are found in the intercondylar notch.
View Article and Find Full Text PDFEmerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges.
Pharmaceutics
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Research Centre for Life Science and Healthcare, Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute (CBI), University of Nottingham Ningbo China, Ningbo 315000, China.
Malignant growth is expected to surpass other significant causes of death as one of the top reasons for dismalness and mortality worldwide. According to a World Health Organization (WHO) study, this illness causes approximately between 9 and 10 million instances of deaths annually. Chemotherapy, radiation, and surgery are the three main methods of treating cancer.
View Article and Find Full Text PDFRelationship Between Perilesional Skin Condition and Survival in Terminally Ill Patients with Pressure Ulcers.
Medicina (Kaunas)
January 2025
SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, 46001 Valencia, Spain.
In the context of palliative care, the aim is to alleviate suffering and improve quality of life, with particular attention to PUs, which have a significant impact on quality of life and survival. This study examines the relationship between perilesional skin condition and survival in terminally ill patients with pressure ulcers (PUs). A descriptive and observational study was conducted in two hospitals in Valencia with a sample of 100 terminally ill patients.
View Article and Find Full Text PDFEEG Responses to Upper Limb Pinprick Stimulation in Acute and Early Subacute Motor and Sensorimotor Stroke: A Proof of Concept.
Transl Stroke Res
January 2025
Department of Rehabilitation Sciences, KU Leuven, B-3001, Leuven, Belgium.
Electroencephalogram (EEG) during pinprick stimulation has the potential to unveil neural mechanisms underlying sensorimotor impairments post-stroke. A proof-of-concept study explored event-related peak pinprick amplitude and oscillatory responses in healthy controls and in people with acute and subuacute motor and sensorimotor stroke, their relationship, and to what extent EEG somatosensory responses can predict sensorimotor impairment. In this study, 26 individuals participated, 10 people with an acute and early subacute sensorimotor stroke, 6 people with an acute and early subacute motor stroke, and 10 age-matched controls.
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