AI Article Synopsis
- NGFI-B is a nuclear receptor that triggers cell death (apoptosis) and can be activated by growth factors like EGF.
- EGF activates the MAP kinase ERK, influencing cell fate decisions between survival and apoptosis.
- Thr-142 on NGFI-B is a key phosphorylation site for ERK2, indicating NGFI-B’s role in linking survival signals from growth factors to apoptosis regulation.
Article Abstract
NGFI-B is an inducible orphan nuclear receptor that initiates apoptosis. Growth factors such as EGF activate the MAP kinase ERK, whose activity may determine if a cell survives or undergoes apoptosis. EGF stimulation of cells leads to phosphorylation of threonine in NGFI-B. Thr-142 of NGFI-B is comprised in a consensus MAP kinase site and was identified as a preferred substrate for ERK2 (but not ERK1) in vitro. These results suggest that NGFI-B may be a molecular target for ERK2 signals and thereby a substrate for crosstalk between a growth factor survival pathway and an inducible regulator of apoptosis.
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| http://dx.doi.org/10.1006/bbrc.2002.6579 | DOI Listing |
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