Purpose: Because of the explosion of genetic information resulting from the Human Genome Project and other developments in genetics and genetic technologies, primary care practitioners in Australia will be expected to have a much greater role in the practice of genetic medicine; however, little is published regarding their knowledge and attitudes to genetics, technologies, or genetics education. This study aimed to determine the genetics knowledge and educational needs of general practitioners (GPs) in Victoria, Australia, and their experiences in dealing with genetics in their practices.
Methods: Qualitative research methods were used primarily to obtain data from focus groups, interviews, and a limited survey.
Results: GPs believed their knowledge of genetics was poor and they felt inadequately prepared to manage patients with genetic conditions. They identified testing and counseling as areas that particularly needed strengthening.
Conclusion: These data, together with GPs' suggestions about educational strategies, are essential for developing appropriate genetics education programs and resources that are relevant for Australian health care.
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http://dx.doi.org/10.1097/00125817-200203000-00004 | DOI Listing |
Water Res
January 2025
Faculty of Geosciences and Civil Engineering, Kanazawa University, Kanazawa 920-1192, Japan; Center for Infectious Disease Education and Research (CiDER), Osaka University, 565-0871, Japan. Electronic address:
Treated effluent of wastewater treatment plants (WWTPs) are major sources of extracellular antimicrobial resistance genes (eARGs) into aquatic environments. This study aimed to clarify the fate and origins of eARGs from influent to treated effluent at a full-scale WWTP. The compositions of eARG and intracellular ARG (iARG) were acquired via shotgun metagenomic sequencing in influent wastewater, activated sludge, and treated effluent of the target WWTP, where identical wastewater was treated by conventional activated sludge (CAS) and membrane bioreactor (MBR) processes.
View Article and Find Full Text PDFPhysiol Rev
January 2025
Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Physical activity is a meaningful part of life, which starts before birth and lasts until death. There are many health benefits to be derived from physical activity, hence, regular engagement is recommended on a weekly basis. However, these recommendations are often not met.
View Article and Find Full Text PDFElife
December 2024
Department of Cadre Cardiology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Metabolic abnormalities associated with liver disease have a significant impact on the risk and prognosis of cholecystitis. However, the underlying mechanism remains to be elucidated. Here, we investigated this issue using Wilson's disease (WD) as a model, which is a genetic disorder characterized by impaired mitochondrial function and copper metabolism.
View Article and Find Full Text PDFPLoS Pathog
January 2025
Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Function-to-find domain (FIIND)-containing proteins, including NLRP1 and CARD8, are vital components of the inflammasome signaling pathway, critical for the innate immune response. These proteins exist in various forms due to autoproteolysis within the FIIND domain, resulting in full-length (FL), cleaved N-terminal (NT), and cleaved C-terminal (CT) peptides, which form autoinhibitory complexes in the steady state. However, the detailed mechanism remains elusive.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Engineering, Free University of Bozen-Bolzano, Bolzano, South Tyrol, Italy.
Appraisal models, such as the Scherer's Component Process Model (CPM), represent an elegant framework for the interpretation of emotion processes, advocating for computational models that capture emotion dynamics. Today's emotion recognition research, however, typically classifies discrete qualities or categorised dimensions, neglecting the dynamic nature of emotional processes and thus limiting interpretability based on appraisal theory. In our research, we estimate emotion intensity from multiple physiological features associated to the CPM's neurophysiological component using dynamical models with the aim of bringing insights into the relationship between physiological dynamics and perceived emotion intensity.
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