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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, Irvine, Irvine, CA, USA.
Background: A case study on a PSEN1 (E280A) carrier with APOECh (R136S) mutation revealed changes in APOE protein function led to a protective effect on AD outcomes. Notably, there is an intriguing disparity between the two hallmark pathologies: a reduction in tauopathy but no change in plaque burden. Given that the APOE protein is predominantly produced by astrocytes and activated microglia, and the APOE gene is among the disease-associated microglia (DAM) genes, it is conceivable that the variance in pathological outcomes may be rooted in the glial response.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Physiopathology in Aging Laboratory (LIM-22), University of São Paulo Medical School, São Paulo, São Paulo, Brazil.
Background: Alzheimer's Disease(AD) patients experience circadian rhythm disorder. The circadian rhythm is synchronized by a master clock, the suprachiasmatic nucleus(SCN), which is spatially well-conserved but a tiny nucleus in the hypothalamus. Little is known about the molecular and pathological changes that occur in the SCN during AD progression.
View Article and Find Full Text PDFNitrite Reduction with HS/Thiol Mediated by Cobalt and Manganese Porphyrins in the Solid State.
Inorg Chem
January 2025
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
The endogenous reduction of nitrite to nitrosyl is drawing increasing attention as a protective mechanism against hypoxic injury in mammalian physiology and as an alternative source of NO, which is involved in a wide variety of biological activities. Thus, chemical mechanisms for this transformation, which are mediated by metallo proteins, are of considerable interest. The study described here examines the reactions of the biomimetic models Co(TTP)(NO) (TTP = meso-tetratolylporphyrinato dianion) and Mn(TPP)(ONO) (TPP = meso-tetraphenyl-porphyrinato dianion) in sublimated solid films with hydrogen sulfide (HS) and with ethanethiol (EtSH) at various temperatures from 77 K to room temperature using in situ infrared and optical spectroscopy.
View Article and Find Full Text PDFDistribution and Conservation of .
Ecol Evol
January 2025
Co-Innovation Center for Sustainable Forestry in Southern China, State Key Laboratory of Tree Genetics and Breeding, College of Life Sciences Nanjing Forestry University Nanjing China.
With global warming and increasingly intensified human activities, numerous species are on the verge of extinction, ca. 28% of living species are threatened globally, although conservation of endangered species has received worldwide attention. It remains unclear if threatened species have been appropriately conserved or not.
View Article and Find Full Text PDFSynergistic interface regulation for achieving fast kinetics and highly reversible zinc metal anodes.
J Colloid Interface Sci
December 2024
Key Laboratory of Automobile Materials, Ministry of Education, and College of Materials Science and Engineering, Jilin University, Changchun 130022, China. Electronic address:
Uncontrolled zinc dendrite growth and adverse side reactions at the Zn anode interface severely limit its practical application. Based on theoretical calculations, this study in situ constructs a functional interface (ICFI Zn) on the Zn anode surface, consisting of a surface-textured structure and a zinc-philic protective layer. Benefiting from the synergistic effect of ion regulation and atomic anchoring of this functional interface, the ICFI Zn anode achieves homogenised regulation of ion fluxes, facilitates ion transport kinetics, effectively suppresses side reactions and guides the deposition of dendrite-free Zn.
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