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Proximal complement inhibitors in paroxysmal nocturnal hemoglobinuria: an abundance of options in a rare disease.
Expert Rev Hematol
January 2025
Department of Pharmacy, Atrium Health, Levine Cancer Institute, Charlotte, NC, USA.
Leadless pacemaker implantation after delayed atrial lead perforation and battery depletion: a case report.
BMC Cardiovasc Disord
December 2024
Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Background: Delayed lead perforation is a rare complication of cardiac implantable electronic device (CIED). Clinical presentations range from completely asymptomatic to pericardial tamponade. Surgical lead extraction is recommended and transvenous lead extraction (TLE) with surgical backup is an alternative method.
View Article and Find Full Text PDFIs diagnostics of Benign Paroxysmal Positional Vertigo with a mechanical rotation chair superior to traditional manual diagnostics? A randomized controlled crossover study.
Front Neurol
December 2024
Balance and Dizziness Center, Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Aalborg University Hospital, Aalborg, Denmark.
Background: Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of vertigo. While various techniques and technologies have improved BPPV diagnostics and treatment, optimizing BPPV healthcare pathways requires a comprehensive understanding of the diagnostic modalities across diverse clinical settings.
Objective: To compare traditional manual BPPV diagnostics (MD) with diagnostics done with the aid of a mechanical rotation chair (MRC) when using videonystagmography goggles with both modalities.
Advancements in PNH treatment: crovalimab's clinical efficacy.
Ann Med Surg (Lond)
December 2024
Faculty of Medicine, Alzaiem Alazhari University, Khartoum, Sudan.
Article Synopsis
- Paroxysmal nocturnal hemoglobinuria (PNH) is a serious blood disorder that involves the breakdown of red blood cells, causing severe symptoms.
- Advances in drug treatments, particularly eculizumab and ravulizumab, have improved patient outlook, and the new complement inhibitor crovalimab shows promise for better results.
- The editorial analyzes clinical trial data and emerging therapies, highlighting crovalimab's potential for more effective and convenient treatment options for a broader patient population.
Intellectual Disability in Episodic Ataxia Type 2: Beyond Paroxysmal Vertigo and Ataxia.
J Clin Neurol
November 2024
Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, Korea.
Article Synopsis
- Episodic ataxia type 2 (EA2) is a genetic disorder causing dizziness and coordination issues, linked to mutations in the calcium channel gene; this study focused on assessing intellectual abilities in affected individuals.
- Researchers evaluated 13 patients in South Korea using the Wechsler Intelligence Scales and found that most had below-average IQ scores, with significant cognitive deficits across multiple areas.
- The findings suggest that individuals with EA2 may experience hidden intellectual disabilities unrelated to epilepsy; therefore, early diagnosis and management are crucial to prevent further brain function decline and may benefit from genetic counseling.
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