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Investigation of the effects of silymarin and vitamin C on kidney damage and aquaporin-2 downregulation in lithium-induced nephrogenic diabetes insipidus in rats.
Drug Chem Toxicol
January 2025
Department of Pathology, Faculty of Veterinary Medicine, Bingöl University, Bingöl, Turkey.
Although lithium (LIT) therapy is key in managing bipolar disorder long-term, prolonged use significantly contributes to acquired Nephrogenic Diabetes Insipidus (NDI). This study examined whether combining Silymarin (SIL) with Vitamin C (Vit C) enhances protection against lithium-induced nephrotoxicity in rats, comparing their individual antioxidant effects as well. Rats subjected to Li exposure were provided with a standard commercial diet supplemented with 80 mmol LiCl per kilogram for 28 days.
View Article and Find Full Text PDFInsights into the Incidence, Course, and Management of Lithium-Induced Hypothyroidism in Real-World Psychiatric Practice in Italy.
Pharmaceuticals (Basel)
October 2024
Department of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.
: Lithium is a cornerstone in the treatment of bipolar disorder (BD). However, lithium use requires careful monitoring of thyroid function due to associated dysfunctions. The aim of our real-world study is to retrospectively evaluate the impact of lithium on thyroid function and how these thyroid alterations can be measured and managed.
View Article and Find Full Text PDFWater acidification aggravates lithium-induced toxicity represented by energy supply, oxidative stress, and cell fate in Daphnia magna neonates.
Sci Total Environ
December 2024
Department of Ecology, Jinan University, Guangzhou 510632, China. Electronic address:
Lithium is extensively utilized in industrial energy production, particularly in lithium-ion batteries, and in pharmaceuticals for the treating clinical mood disorders. Consequently, lithium is frequently detected in various environmental matrices. It has been reported to cause a range of toxic effects on aquatic organisms including oxidative stress, neurological disorders, and reproductive suppression.
View Article and Find Full Text PDFIntranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD mice.
bioRxiv
December 2024
Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
Article Synopsis
- * Intranasal LiCl in RFV was found to have a higher brain/blood lithium concentration ratio, providing better protection against memory loss and depressive behaviors without causing side effects or organ toxicity.
- * The neuroprotective effects of intranasal LiCl are linked to its ability to inhibit inflammation and the pyroptosis pathway, suggesting it could be a promising treatment for dementia and depression with minimal risks.
Lithium-induced apoptotic cell death is not accompanied by a noticeable inflammatory response in the kidney.
Front Physiol
August 2024
Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Lithium (Li) therapy is a valuable tool in psychiatric practice that remains underutilized due to safety concerns. Excessive plasma Li levels are nephrotoxic and can trigger a local immune response. Our understanding of the immunomodulatory effects of Li in the kidney is fragmentary.
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