We developed a polysaccharide-specific flow cytometric opsonophagocytic assay (OPA) for the simultaneous measurement of functional antibody to Neisseria meningitidis serogroups A, C, Y, and W135. OPA titers significantly correlated with serum bactericidal assay titers for all serogroups tested (mean r = 0.96; P < 0.001). OPA could be used in meningococcal vaccine evaluation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC119948 | PMC |
| http://dx.doi.org/10.1128/cdli.9.2.485-488.2002 | DOI Listing |
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