A healthy immunocompetent 40-year-old man presented with spotted hyperpigmentation of the face. Skin-biopsies taken from these lesions revealed slight acanthosis of the epidermis with vacuolization within the keratinocytes in the upper malpighian layer similar to HPV-induced cytopathic viral effects. Polymerase chain reaction analysis and subsequent direct DNA sequencing could clearly demonstrate the presence of HPV 29 DNA in the hyperpigmented macules. To our knowledge, this is the first report of facial hyperpigmented lesions induced by HPV 29.
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