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[Translated article] Relationship between lactate dehydrogenase and survival in patients with non-small-cell lung cancer receiving immunotherapy.
Farm Hosp
January 2025
Servicio de Farmacia, Hospital Universitario de la Ribera, Alzira, Spain.
Objective: The expression level of programmed death ligand 1 (PD-L1) is the only approved biomarker for predicting response to immunotherapy, yet its efficacy is not always consistent. Lactate dehydrogenase (LDH) has been associated with tumor aggressiveness and poorer prognosis across various cancer types and may serve as a useful biomarker for monitoring treatment response. The objective of this study is to analyze the relationship between LDH levels prior to the start of treatment with immune checkpoint inhibitors (ICIs) and clinical outcomes in patients with non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFExploring synergistic interactions of ethyl acetate removal and community ecology using magnetite-entrapped biofilters.
Environ Res
January 2025
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Xiamen Engineering Research Center of Industrial Wastewater Biochemical Treatment, Xiamen 361021, China; Fujian Provincial Research Center of Industrial Wastewater Biochemical Treatment (Huaqiao University), Xiamen 361021, China. Electronic address:
Emissions of ethyl acetate (EA) exhaust from industrial sources can cause environmental and health risks. EA can be effectively removed by biological filtration with low operating costs and promising good benefits. This study demonstrated the synergistic effect of using magnetite and pebbles as bio-packing in promoting microbial activity and microbial abundance for EA degradation.
View Article and Find Full Text PDFAn aptamer-based electrochemical sensor for the quantification of the malaria biomarker lactate dehydrogenase.
Biosens Bioelectron
January 2025
Barcelona Institute for Global Health (ISGlobal), Barcelona, 08036, Spain; INTERFIBIO Research Group, Departament d'Enginyeria Química, Universitat Rovira i Virgili, Tarragona, 43007, Spain. Electronic address:
Malaria is one of the most deadly infectious diseases, causing the death of hundreds of thousands of patients each year. Global efforts to combat malaria necessitate the implementation of novel rapid diagnostic tests deployable at the point of care. Here, we present the development of an electrochemical aptamer-based (EAB) sensor for the quantification of the malaria biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH).
View Article and Find Full Text PDFEculizumab treatment for Chinese patients with hemolytic paroxysmal nocturnal hemoglobinuria (PNH): efficacy and safety - a single-center study.
Hematology
December 2025
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
Objective: To evaluate the short-term efficacy and safety of eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) in China.
Method: Data were retrospectively collected from patients with PNH who received at least 3 months of full-dose eculizumab. Changes in clinical and laboratory indicators after 1, 3, and 6 months of eculizumab therapy and at the end of follow-up were documented.
Corrigendum: New model to predict survival in advanced pancreatic ductal adenocarcinoma patients by measuring GGT and LDH levels and monocyte count.
Front Oncol
January 2025
Angiogenesis Group, Center for Biomedical Research of La Rioja (CIBIR), Logroño, Spain.
[This corrects the article DOI: 10.3389/fonc.2024.
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