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Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion.
Physiol Genomics
July 2022
Department of Ophthalmology, Stanford University, Palo Alto, California.
Limited reports exist regarding adeno-associated virus (AAV) biodistribution in swine. This study assessed biodistribution following antegrade intracoronary and intravenous delivery of two self-complementary serotype 9 AAV (AAV9sc) biologics designed to target signaling in the cardiomyocyte considered important for the development of heart failure. Under the control of a cardiomyocyte-specific promoter, AAV9sc.
View Article and Find Full Text PDFThe Effect of Functional and Intra-Coronary Imaging Techniques on Fluoroscopy Time, Radiation Dose and Contrast Volume during Coronary Angiography.
Sci Rep
April 2020
Universidad de Monterrey, Facultad de Medicina, Especialidades Médicas. Av. Ignacio Morones Prieto 4500, Jesús M. Garza, 66238, San Pedro Garza García, Nuevo Leon, Mexico.
The aim was to analyze the effect of fractional flow reserve (FFR), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on fluoroscopy time (FT), radiation dose (RD) and contrast volume (CV) in patients undergoing coronary angiography. This case-control study included consecutive patients above the age of 18, who underwent coronary angiography. FT, RD, and CV after each procedure were retrospectively recorded.
View Article and Find Full Text PDFTwo decades after coronary radiation therapy: A single center longitudinal clinical study.
Catheter Cardiovasc Interv
September 2020
University Heart Center, University Hospital Zürich, Zürich, Switzerland.
Objectives: The aim of this study was to evaluate the very long-term clinical outcome after radioactive stent (RS) implantation and intracoronary β radiation brachytherapy (IRBT).
Background: Radioactive stents (RS) and intracoronary β radiation brachytherapy (IRBT) were introduced to prevent restenosis after percutaneous coronary intervention (PCI). Both techniques were associated with a higher incidence of major adverse cardiac events (MACE) in the short and intermediate-term follow up as compared to conventional PCI.
Edge effect after intracoronary beta radiation brachytherapy and bare metal stent implantation: the pathway for very late stent failure.
Minerva Cardioangiol
February 2018
Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium.
A retrospective analysis of catheter-based sources in intravascular brachytherapy.
Brachytherapy
December 2017
Medical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Purpose: Coronary artery disease involves the deposition of plaque along the walls of a coronary artery leading to narrowed or blocked vessels (stenosis) and is one of the main causes of death in developed countries. Percutaneous transluminal coronary angioplasty (PTCA) is used to reverse stenosis. Restenosis (renarrowing) of the treated vessel is a major complication of PTCA.
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