[reaction: see text] A novel, nonacetal (trifluoromethyl)deoxoartemisinin was prepared with good stereoselectivity. This compound was obtained by debromination of the 10 alpha-CF3-10-bromodeoxoartemisinin in the presence of tributyltin hydride at reflux in toluene without alteration of the endoperoxide bridge. It presented a reasonable antimalarial activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol017227z | DOI Listing |
Publication Analysis
Top Keywords
synthesis alpha-trifluoromethyldeoxoartemisinin
4
alpha-trifluoromethyldeoxoartemisinin [reaction
4
[reaction text]
4
text] novel
4
novel nonacetal
4
nonacetal trifluoromethyldeoxoartemisinin
4
trifluoromethyldeoxoartemisinin prepared
4
prepared good
4
good stereoselectivity
4
stereoselectivity compound
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!