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COVID-19-Associated Immune Thrombocytopenic Purpura in a Hemodialysis Patient.
J Blood Med
November 2024
Kidney Institute of PLA, Department of Nephrology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, People's Republic of China.
Background: Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection has been a global threat since the end of 2019. Although the main clinical manifestation of coronavirus disease 2019 (COVID-19) is respiratory, its range of clinical manifestation is extensive and may include various systems, including hematological disorders, such as lymphopenia, thrombotic events, thrombocytopenia and immune thrombocytopenic purpura (ITP). The present case was the first one that aimed to raise awareness of ITP induced by COVID-19 in patients undergoing maintenance hemodialysis.
View Article and Find Full Text PDFVadadustat Three Times Weekly in Patients With Anemia Due to Dialysis-Dependent CKD.
Am J Kidney Dis
November 2024
Emory University School of Medicine, Atlanta, GA.
Article Synopsis
- The study investigates the effectiveness and safety of using vadadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, as an alternative to the erythropoiesis-stimulating agent methoxy polyethylene glycol-epoetin beta (MPG-EPO) in treating anemia for patients with chronic kidney disease (CKD) who are on dialysis.
- This Phase 3b trial involved 456 adult participants, randomized into three groups receiving either vadadustat (at two different doses) or MPG-EPO, for up to 52 weeks, with a focus on changes in hemoglobin levels.
- Results showed that vadadustat was noninferior to MPG-EPO regarding hemoglobin change
Equity-centered adaptive sampling in sub-sewershed wastewater surveillance using census data.
Environ Sci (Camb)
December 2024
Department of Civil and Environmental Engineering, University of California Davis Davis California 95616 USA
Sub-city, or sub-sewershed, wastewater monitoring for infectious diseases offers a data-driven strategy to inform local public health response and complements city-wide data from centralized wastewater treatment plants. Developing strategies for equitable representation of diverse populations in sub-city wastewater sampling frameworks is complicated by misalignment between demographic data and sampling zones. We address this challenge by: (1) developing a geospatial analysis tool that probabilistically assigns demographic data for subgroups aggregated by race and age from census blocks to sub-city sampling zones; (2) evaluating representativeness of subgroup populations for COVID-19 wastewater-based disease surveillance in Davis, California; and (3) demonstrating scenario planning that prioritizes vulnerable populations.
View Article and Find Full Text PDFBehavioral changes and transcriptional regulation of mesolimbic dopaminergic genes in a mouse model of binge eating disorder by diet intermittent access.
J Nutr Biochem
January 2025
Laboratório de Genética Animal e Humana, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Binge Eating Disorder (BED) is among the most prevalent eating disorders worldwide. It is characterized by recurrent episodes of excessive consumption of palatable foods in short periods, accompanied by a sense of loss of control and distress around the episode, which tends to worsen over time. The mesolimbic dopaminergic system influences on reinforcement and reward-seeking behaviors is implicated in the disorder's pathogenesis.
View Article and Find Full Text PDFExploring acupuncture as a treatment for insomnia in perimenopausal women with stable angina pectoris: A protocol for a randomized, double-blind, placebo-controlled clinical trial.
PLoS One
April 2024
Department of School of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Background: Insomnia has emerged as a major public health issue jeopardizing human wellbeing. Furthermore, insomnia and angina arise concomitantly and exert reciprocal effects. Multiple studies suggest that perimenopausal females are more prone to experiencing both angina and insomnia, consequently substantially compromising their quality of life.
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